农药使用与人群脂代谢水平的关系

Relationship between pesticide exposure and lipid metabolism in population

目的探讨杀虫剂和除草剂使用对脂代谢的影响。方法于2020年11月,基于美国国家健康与营养调查(NHANES)公开数据库,选取2011至2014年脂代谢报告,选择20~65岁有人口学信息、农药使用情况和4种脂代谢指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)和低密度脂蛋白胆固醇(LDLC)]数据的调查者作为研究对象,共3039人。依据是否使用杀虫剂将研究对象分为杀虫剂组(320人)和非杀虫剂组(2719人),依据是否使用除草剂将研究对象分为除草剂组(156人)和非除草剂组(2883人)。分析一般人口学及脂代谢指标分布情况,用分层多元线性回归分析农药使用与脂代谢的关系。结果3039名研究对象中男性和女性分别1509人(49.7%)和1530人(50.3%),男性年龄(39.7±12.0)岁,女性年龄(40.2±12.0)岁。女性中除草剂组HDLC[(55.4±15.0)mg/dl]浓度低于非除草剂组[(58.2±14.2)mg/dl](P<0.05)。多元线性回归分析结果表明,使用除草剂与TC、LDLC、LDLC/HDLC升高有关(b=0.038、0.048、0.050,均P<0.05),与HDLC降低有关(b=-0.044,P<0.05)。使用除草剂与女性HDLC降低、LDLC和LDLC/HDLC升高有关(b=-0.050、0.062、0.067,均P<0.05)。结论除草剂暴露可引起脂代谢改变,对女性效应更明显。

Objective To investigate the effect of pesticides and herbicides on lipid metabolism.Methods In November 2020,Based on the data of the national health and Nutrition Survey(NHANES)(2011-2014),select the population aged 20~65 who have demographic information,pesticide use and data of four lipid metabolism indicators[total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDLC)and low density lipoprotein cholesterol(LDLC)](n=3039).The subjects were divided into insecticide group(320 people)and non insecticide group(2719)according to the use of insecticides,and herbicide group(156 people)and non herbicide group according to the use of herbicides.Results Among the 3039 subjects,the males and female were 1509(49.7%)and 1530(50.3%)respectively.The males age was(39.7±12.0)years and the females age was(40.2±12.0)years The concentration of HDLC in the NHANES(55.4±15.0)mg/dl was lower than that of(58.2±14.2)mg/dL in the non herbicide group(P<0.05)(b=-0.044,P<0.05).The results showed that the use of herbicides was related to the decrease of HDLC and the increase of LDLC and LDLC/HDLC in female population(b=-0.050,0.062,0.067,all P<0.05).Conclusion Herbicide exposure can cause the change of lipid metabolism,and the effect on female population is more obvious.