小肠细菌过度生长与肠易激综合征的关系及氢呼气试验的应用

Relationship between Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome Application of Hydrogen Test and Hydrogen Breath Test

肠易激综合征(IBS)是一种功能性疾病,由于社会节奏的增快、生活和工作压力的增加,其发病率也在逐年上升。IBS发病机制尚不清楚,病情易反复,治疗上多属于对症治疗,对人们的生活、心理以及经济都造成了巨大影响。随着人们对肠易激综合征的深入研究,发现肠道菌群失衡中小肠细菌过度生长可能对肠易激综合征尤其是腹泻型肠易激综合征的发病扮演了重要角色。因此检测小肠细菌过度生长为研究肠易激综合征的肠道菌群失衡、以及通过调节肠道菌群来治疗肠易激综合征提供了新的方式。氢呼气试验作为一种无创、方便的检测小肠细菌过度生长的方式受到临床的广泛应用。本文就小肠细菌过度生长和肠易激综合征的关系、小肠细菌过度生长的检测方法氢呼气试验的应用做一综述。

Irritable bowel syndrome(IBS) is a functional disease, its incidence is also increasing year by year due to the increase of social rhythm and the increase of life and work pressure. The pathogenesis of IBS is not clear, the disease is easy to repeat, and most of the treatment belongs to symptomatic treatment, which has a great impact on people’s life, psychology and economy. With the in-depth study of irritable bowel syndrome, it is found that intestinal flora imbalance and overgrowth of small and medium-sized bacteria may play an important role in the pathogenesis of irritable bowel syndrome, especially diarrhea irritable bowel syndrome. Therefore, the detection of intestinal bacterial overgrowth provides a new way to study the imbalance of intestinal flora in irritable bowel syndrome and to treat irritable bowel syndrome by regulating intestinal flora. Hydrogen breath test is widely used in clinic as a non-invasive and convenient way to detect the overgrowth of bacteria in the small intestine. This article reviews the relationship between intestinal bacterial overgrowth and irritable bowel syndrome and the application of hydrogen breath test to detect intestinal bacterial overgrowth.