摘要
以人参皂苷Rg_(1)为原料、羟丙基-β-环糊精为载体、人参皂苷Rg_(1)水溶性纳米颗粒粒径为评价指标,通过单因素试验、正交试验优化制备工艺,制备人参皂苷Rg_(1)水溶性纳米颗粒;应用红外光谱、扫描电镜、X射线衍射、热质量分析、体外缓释试验,对人参皂苷Rg_(1)水溶性纳米颗粒进行表征。结果表明:人参皂苷Rg_(1)水溶性纳米颗粒的最优制备工艺——m(人参皂苷Rg_(1))∶V(水)为1 g∶20 mL、m(羟丙基-β-环糊精)∶m(人参皂苷Rg_(1))为4 g∶1 g、反应温度为25℃、反应时间为45 min;制备的人参皂苷Rg_(1)水溶性纳米颗粒平均粒径为(405±20)nm,具有良好的水溶性和体外释放效果。
Using ginsenoside Rg_(1)as raw material,hydroxypropyl-β-cyclodextrin as carrier,and ginsenoside Rg_(1)water-soluble nanoparticle size as evaluation index,the preparation process was optimized by single factor experiment and orthogonal experiment,and the water-soluble ginsenoside Rg_(1)was prepared.Nanoparticles;using infrared spectroscopy,scanning electron microscopy,X-ray diffraction,thermal mass analysis,and in vitro sustained-release tests,the optimal preparation process for ginsenoside Rg_(1)water-soluble nanometer m(ginsenoside Rg_(1))∶V(water)is 1 g∶20 mL,m(hydroxypropyl-β-cyclodextrin)∶m(ginsenoside Rg1)is 4 g∶1 g,the reaction temperature is 25℃,and the reaction time is 45 min;the average particle size of the prepared ginsenoside Rg_(1)water-soluble nanoparticles is(405±20)nm,and has good water solubility and in vitro release effect.
作者
柴艳敏
陈宁
张紫微
周婉梅
郑威
Chai Yanmin;Chen Ning;Zhang Ziwei;Zhou Wanmei;Zheng Wei(Harbin University of Commerce,Harbin 150076,P.R.China)
出处
《东北林业大学学报》
CAS
CSCD
北大核心
2022年第2期130-134,共5页
Journal of Northeast Forestry University
基金
哈尔滨商业大学青年创新人才支持计划(2019CX09)
黑龙江省博士后启动基金(LBH-Q20103)。