Axin2阳性细胞在牙周组织发育与再生中的作用

The role of Axin2^(+) cells in periodontal tissue development and regeneration

WNT信号通路作为进化中高度保守的信号通路,在牙周组织生长发育和损伤修复中发挥重要调控作用。Axin相关蛋白Axin2作为WNT信号通路的直接效应分子,可对WNT效应细胞进行良好标记。研究显示,牙周组织内Axin2阳性(Axin2^(+))细胞具有自我更新、复制及多向分化潜能。本文对Axin2^(+)细胞在牙周组织发育过程中的时空分布,以及Axin2^(+)细胞在牙周组织发育、再生和组织改建中的作用及其调控机制研究进展作一综述,以期为牙周组织再生提供新的思路。现有研究表明,Axin2^(+)细胞是牙周组织发育的重要干细胞来源,Axin2^(+)细胞在拔牙窝愈合、种植体骨整合、牙周组织改建和结合上皮再生中均发挥重要作用。Axin2^(+)细胞的功能受到经典WNT信号通路的正向调控。然而,其他信号通路对Axin2^(+)细胞的调控机制仍有待阐明。

As a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair. The Axin-associated protein Axin2 is a direct effector molecule of the WNT signaling pathway and labels WNT-responsive cells well. Studies have shown that Axin2-positive(Axin2^(+))cells in the periodontium have the potential for self-renewal, replication and multidirectional differentiation. This article reviews the temporal and spatial distribution of Axin2^(+)cells in periodontal tissue development and the role and regulatory mechanism of Axin2^(+)cells in periodontal tissue development, regeneration and tissue remodeling to provide new ideas for periodontal tissue regeneration. The literature review showed that Axin2^(+)cells were the main cell source of periodontium development, and Axin2^(+)cells played essential roles in tooth extraction socket healing, implant osseointegration, periodontal tissue remodeling and junctional epithelium regeneration. The function of Axin2^(+)cells was positively regulated by the canonical WNT signaling pathway. However, the regulatory mechanisms of other signaling pathways on Axin2^(+)cells remain to be elucidated.