益生菌-水凝胶递送系统的研究进展及应用潜力

Research progress and potential application in oral cavity of hydrogel-based probiotic delivery systems

益生菌是能够改善人体胃肠道、皮肤、阴道和口腔四大微生态系统的微生物群,常借由递送系统到达靶点以用于预防和治疗目的。水凝胶是最常见的递送系统载体,最近的研究针对水凝胶材料的改良主要可分为基质结构、填充物和外部涂层3个方面,新型水凝胶能够更好地帮助益生菌适应加工、储存环境及人体内微环境。人体不同微环境下益生菌对递送载体具有不同需求。口腔微环境的独特特性会成为益生菌定殖的新挑战,而水凝胶恰好能解决这些问题。水凝胶的应用必将加速口腔益生菌在临床研究和药物研发上的进程。

Probiotics can improve the microbiota of human oral cavity, gastrointestinal tract, skin, and vagina and reach the targets via delivery systems for preventive and therapeutic purposes. Hydrogel is currently accepted as the most common carrier of delivery systems. The recent studies aiming at improving hydrogel materials mainly focus on matrix structure, bulking agents, and external coating.The novel hydrogel contributes to the adaptation of probiotics to the processing and storage environment, as well as human body microenvironment. Probiotics have varying requirements for delivery carriers in different human microenvironments. The specific characteristics of the oral microenvironment pose a new challenge to the colonization of probiotics, to which hydrogel may be a solution. The application of hydrogel will expedite the course of clinical research and pharmaceutical development of oral probiotics.