静脉溶栓联合介入疗法对急性脑梗死患者血清学指标及血管再通的影响

Effects of Intravenous Thrombolysis Combined with Interventional Therapy on Serological Indexes and Vascular Recanalization in Patients with Acute Cerebral Infarction

目的:探究静脉溶栓与介入疗法联合在急性脑梗死中的应用意义。方法:选取2019年11月-2020年11月孝感市第一人民医院收治的80例急性脑梗死患者,按照随机数字表法将其分为对照组和观察组,每组40例。对照组采用静脉溶栓,观察组采用静脉溶栓联合介入疗法。比较两组疗效、神经功能、血清学指标[血清神经生长因子(NGF)、髓鞘碱性蛋白(MBP)]、血管再通情况。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组NIHSS评分比较,差异无统计学意义(P>0.05);治疗1、2周,观察组NIHSS评分均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组血清NGF、MBP水平比较,差异均无统计学意义(P>0.05);治疗2周,观察组的血清NGF高于对照组,血清MBP低于对照组,差异均有统计学意义(P<0.05)。观察组血管再通率高于对照组,差异有统计学意义(P<0.05)。结论:联合静脉溶栓及介入疗法对急性脑梗死患者进行治疗,可有效改善患者血清学指标及神经功能,可促进血管再通,疗效显著。

Objective:To explore the application significance of intravenous thrombolysis combined with interventional therapy in acute cerebral infarction.Method:A total of 80 patients with acute cerebral infarction admitted to Xiaogan First People’s Hospital from November 2019 to November 2020 were selected,they were divided into control group and observation group according to random number table method,with 40 patients in each group.The control group received intravenous thrombolysis,and the observation group received intravenous thrombolysis combined with interventional therapy.The therapeutic effect,neurological function,serological indexes[serum nerve growth factor(NGF),myelin basic protein(MBP)]and vascular recanalization were compared between two groups.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in NIHSS scores between two groups(P>0.05);1 and 2 weeks of treatment,NIHSS scores of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant difference in serum NGF and MBP levels between two groups(P>0.05);2 weeks of treatment,serum NGF of the observation group was higher than that of the control group,while serum MBP of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).The rate of vascular recanalization of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:The combination of intravenous thrombolysis and interventional therapy in the treatment of patients with acute cerebral infarction can effectively improve the serological indexes and neurological function of patients,and promote the vascular recanalization of blood vessels,the effect is significant.