摘要
An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes is described,providing a general method for installation of the challenging alkyl fragments containing a-electron-withdrawing groups into a-trifluoromethyl alkenes.Mechanistic studies suggest that this process involves an SN2,-type synthetic route in the absence of transition-metal catalysts or photocatalysis.Moreover,this protocol can easily be scaled up,and successfully applied to the modification of biologically active molecules,thus complementing methodologies that give access to structurally versatile gem-difluoroalkenes.
基金
the support from the National Natural Science Foundation of China(Nos.21732006,51821006 and 51961135104)
the Natural Science Foundation of Anhui(No.2008085MB40)
the USTC Research Funds of the Double First Class Initiative(No.YD2060002003)
The authors thank Xi Lu(University of Science and Technology of China)for insightful discussion during the preparation of the manuscript.
