针刺联合膈下逐瘀汤治疗湿热型溃疡性结肠炎患者临床疗效观察

Clinical Observation of Acupuncture Combined with Diaphragm-Xia Zhuyu Decoction in The Treatment of Damp-Heat Ulcerative Colitis

目的:观察针刺联合膈下逐瘀汤治疗湿热型溃疡性结肠炎的临床疗效,分析其对患者血清炎性因子与脑肠肽神经递质水平的影响。方法:选取80例活动期溃疡性结肠炎(湿热型)患者作为研究对象,通过随机分组的方式将患者分为对照组与治疗组,各40例。两组患者均接受基础治疗,对照组在此基础上采用膈下逐瘀汤治疗,治疗组接受针刺鬼眼穴联合膈下逐瘀汤治疗。两组患者均连续治疗4周,疗程结束后对两组患者疗效情况、结肠黏膜病变及愈合情况、血清炎性因子、脑肠肽神经递质水平、生活质量进行分析比较,并进行随机回访。结果:经治疗,治疗组治疗总有效率为92.50%,明显高于对照组的70.00%(P<0.05);治疗后,两组患者Baron评分、Geboes指数及病变活动指数较治疗前均有所下降,且治疗组均明显低于对照组(P<0.05);治疗后治疗组肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平均明显低于对照组(P<0.05);治疗后,治疗组患者炎症性肠病质量问卷(IBDQ)各维度评分均明显高于对照组(P<0.05);治疗组6个月内疾病复发率为12.50%,明显低于对照组37.50%(P<0.05)。结论:针刺联合膈下逐瘀汤治疗可显著提高湿热型溃疡性结肠炎的临床疗效,调节患者血清炎性因子与脑肠肽神经递质水平,改善患者肠道黏膜功能,提高患者生活质量。

Objective:To observe the clinical efficacy of acupuncture combined with Diaphragm-xia Zhuyu decoction in the treatment of damp-heat ulcerative colitis,and to analyze the effects of acupuncture on serum inflammatory factors and neurotransmitter levels of brain-intestinal peptide.Methods:80 patients with active ulcerative colitis(damp-heat type)were selected as the research object,and the patients were randomly divided into control group and treatment group,with 40 cases in each group.Patients in both groups were treated with basic treatment,the control group was treated with Diaphragm-xia Zhuyu Decoction on this basis,and the treatment group was treated with ghost eye acupoint combined with Diaphragm-xia Zhuyu Decoction.Patients in both groups were treated for 4 weeks continuously.After the course of treatment,the efficacy,colonic mucosal lesions and healing,serum inflammatory factors,neurotransmitter levels of brain-intestinal peptides and quality of life of the two groups were analyzed and compared,and follow-up visits were conducted.Results:After treatment,the total effective rate of treatment group was 92.50%,which was significantly higher than that of control group(70.00%,P<0.05).After treatment,baron score,geboes index and pathological activity index in 2 groups were decreased compared with before treatment,and the treatment group was significantly lower than the control group(P<0.05);After treatment,the levels of tumor necrosis factor(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in treatment group were significantly lower than those in control group(P<0.05);After treatment,the scores of each dimension of IBDQ in treatment group were significantly higher than those in control group(P<0.05);The disease recurrence rate in the treatment group was 12.50%,which was significantly lower than that in the control group(37.50%,P<0.05).Conclusion:Acupuncture combined with Diaphragm-xia Zhuyu decoction can significantly improve the clinical efficacy of damp-heat ulcerative colitis,regulate the levels of serum inflammatory factors and neurotransmitter of brain intestinal peptide,improve the intestinal mucosal function of patients,and improve the quality of life of patients.