基于数据挖掘技术探析《类证治裁》中治疗痰饮的用药规律

The Analysis of the Medication Rules of Treating Phlegm Drink in Like Syndrome Treatment Based on Data Mining Technology

目的:基于数据挖掘技术探讨《类证治裁》中治疗痰饮的用药规律。方法:按照纳入标准统计《类证治裁》中所记载治疗痰饮的方剂,运用MS Excel 2016对其方药进行频数、功效分类、性味及归经统计,分别采用SPSS Modeler 18.0、SPSS Statistics 26.0对方药进行关联规则及聚类分析。结果:筛选出符合纳入标准的方药62首,涉及中药104味,其中频次较高的有13味药;以补虚药、化痰止咳平喘药、解表药为主,药性以温、平、寒为主,药味以甘、辛、苦为主,归经多属脾、肺经;根据高频药物(频数≥6)关联规则分析得到核心药对和药组有5条,1首核心配伍,聚类分析可得出3个药物聚类组合。结论:《类证治裁》中治疗痰饮方剂的核心药物有茯苓、半夏、生姜、甘草、白术、陈皮、人参等,核心方为二陈汤及六君子汤,其组方思路遵从"温药和之"治疗总则,强调固护后天之本,以燥湿化痰、理气健脾、和胃化饮为主要治则,体现了林佩琴治疗痰饮的学术思想,可为临床治疗提供一定的依据。

Objective:To discuss the medication rule of prescriptions and academic thoughts of the treatment for phlegm retention in Like Syndrome Treatment which was Based on data mining technology.Methods:According to the inclusive criteria,the prescriptions for the treatment of phlegm retention in Like Syndrome Treatment were counted,MS Excel 2016 was used to gather the stastustics of the prescriptions of frequency,function classification,nature and taste,and meridian statistics.SPSS Modeler 18.0 and SPSS Statistics 26.0 were used for analysising the association rules and cluster respectively.Results:Total of 62 prescriptions that meeting the criteria were screened,involving 104 Chinese medicines,in which 13 drugs were used frequently.Most of the Chinese medicines involved are tonics,expectorants,antitussive and antiasthmatics,the drug properties are mainly warm,mild and cold,their tastes are mainly sweet,pungent and bitter,and their channel tropisms mostly belonged to Pi and lung meridians.According to the association rules of high frequency drugs which frequency is more than 6,the core drug pairs were divided into five groups.Aslo,most of them could be divided into 4 categories by the cluster analysis.Conclusion:The core drugs which treated with Phlegm Decoction in Like Syndrome Treatment are Poria cocos,Pinellia ternata,Ginger,Licorice,Atractylodes macrocephala,Pericarpium citri reticulatae,Ginseng,et al,and the core prescriptions were Erchen decoction and Liujunzi Decoction.The thinking of the composition of prescription for treating phlegm retention in Like Syndrome Treatment was followed the general principle of warming medicine melting phlegm,and in which the protection of the acquired foundation was emphasized,to remove dampness to reduce phlegm,regulate qi and invigorate Pi,and warm stomach to eliminate phlegm which as the main treatment principles.These results reflects the academic thoughts of Lin Peiqin on treating phlegm retention,and provides a certain basis for clinical treatment of this disease and symptom.