维生素D与动脉性肺动脉高压

Vitamin D and pulmonary arterial hypertension

动脉性肺动脉高压(PAH)是一种以肺动脉压升高为特征且预后极差的疾病。目前具有适应证的药物可改善肺动脉高压患者预后,但无法治愈,探讨其发病机制、寻找新的治疗靶点是当前PAH研究热点。维生素D是一种类固醇激素,在体内活性形式为1,25-二羟维生素D3。近年来维生素D缺乏已被证明与多种自身免疫病的发病有关。维生素D缺乏可影响PAH的发生,本综述探讨维生素D缺乏在PAH发生、发展中的作用,并讨论维生素D补充对PAH的治疗意义,旨在为药物治疗肺动脉高压提供新思路。

Pulmonary arterial hypertension(PAH)is a disorder characterized by elevated pulmonary arterial pressure and poor prognosis.Although the current drugs for indications can improve the prognosis of patients with pulmonary hypertension,those patients are inevitably unable to be cured.It is a current hot research topic for PAH to explore its pathogenesis and identify new therapeutic targets.Vitamin D is a steroid hormone with the active form of 1,25-dihydroxyvitamin D3 in the body.In recent years,vitamin D deficiency has been linked to the development of many autoimmune diseases.Vitamin D deficiency may affect the pathogenesis of PAH.This review discusses the role of vitamin D deficiency in the pathogenesis and development of PAH,and investigate the significance of vitamin D supplementation in the treatment of PAH,aiming to provide a new idea for drug treatment of PAH.