摘要
The effective detecting ONOO^(-)variations in vivo is of great importance to well understand the complex pathophysiological processes. We reported here a photoacoustic(PA) probe AZB-1 for imaging ONOO;in vivo. AZB-1 showed an originally strong photoacoustic signal at 660 nm. And its PA signal can be turned off by shutting the ICT effect caused by the conjugated electron withdrawing group at 2-position of the aza-BODIPY core. Moreover, the probe was successfully employed to imaging ONOO^(-)variations in inflammatory mice models. Wisely utilized this strategy may serve as powerful platforms for the preparation of novel PA chemosensors.
基金
the National Natural Science Foundation of China (Nos. 21662037, 21762045, 21911540466)
Shandong Provincial Natural Science Foundation (No. ZR2019YQ12)
China Postdoctoral Science Foundation (No. 219M652306)
Taishan Scholar Project (No. tsqn 201812049) for supporting this work
supported through the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1A6A3A04004954) to S. Lee。
