实验动物牛棒杆菌感染危害与防控措施

Harm and Control Measures of Corynebacterium bovis Infection in Laboratory Animals

本文对棒状杆菌(Corynebacterium spp.)感染引起的过度角化症的流行病学特点、临床症状、诊断方法和防控净化措施的研究进展进行综述。结合啮齿类实验动物饲养管理特点,推荐有效的动物设施灭菌净化方法以及科学的预防控制措施。当动物设施被诊断出牛棒状杆菌(Corynebacterium bovis)感染,建议对饲养室内的所有动物实施安乐死和无害化处理,并尽快用过氧化氢(H_(2)O_(2))蒸汽对饲养室进行消毒灭菌,不建议保留和治疗被感染动物。此外,本文还介绍了如何在动物模型的人类肿瘤组织移植过程中,消除牛棒状杆菌感染的方法。牛棒状杆菌感染重在预防,应格外注意控制外来动物以及对肿瘤移植物和细胞系进行使用前检测。希望本文为防控牛棒杆菌提供参考方法。

The article summarize the research about epizootiologic features,clinical symptoms,diagnostic method and recycling an animal room infected by Corynebacterium bovis.According to the characteristics of feeding and management of rodents,it recommend an effective method for recycling an ineected barrier room and a preventive control measures for SPF level facility.Once the animal facility is detected C.bovis,it is recommend that all animals in this room should be euthanasia and sterilize the room with hydrogen peroxide as quickly as possible.Treatment of animals infected with C.bovis is not recommended.In addition,preventive measures against C.bovis infection are important,and should pay extra attention to control exotic animals and pre-use testing of transplantation and cell line in order to elininate C.bovis during tumor tissue transplantation.It is hoped that providing a reference method for prevent and control C.bovis.