胞磷胆碱联合丁苯酞软胶囊治疗老年脑梗死后血管性痴呆的效果及对认知功能的影响

Efficacy of citicoline combined with butylphthalide soft capsule on elderly patients with vascular dementia after cerebral infarction and its effects on cognitive function

目的探讨胞磷胆碱联合丁苯酞软胶囊治疗老年脑梗死后血管性痴呆(VD)的效果及对认知功能的影响。方法抽取2018年1月至2019年12月于平煤神马医疗集团总医院收治的65例老年脑梗死后VD患者为研究对象,使用随机数字表法分为对照组(32例)和观察组(33例)。对照组患者予以胞磷胆碱治疗,观察组患者在对照组基础上联合丁苯酞软胶囊治疗。比较两组患者治疗8周后治疗效果,比较两组患者治疗前、治疗8周后认知功能、生化指标、脑血流情况,比较两组患者治疗期间不良反应。结果治疗8周后,两组患者总有效率比较,P>0.05;两组患者简易精神状态检查量表(MMSE)评分较治疗前升高,且观察组高于同期对照组(P<0.05);两组患者同型半胱氨酸(Hcy)、三酰甘油(TG)均较治疗前下降,且观察组低于同期对照组,而两组患者基底动脉(BA)、大脑前动脉(ACA)、椎动脉(VA)水平均较治疗前高,且观察组高于同期对照组(P<0.05);治疗期间,两组患者不良反应发生情况比较,P>0.05。结论胞磷胆碱联合丁苯酞软胶囊治疗老年脑梗死后VD患者疗效与单用胞磷胆碱相近,但联合用药能改善患者认知功能、调节生化指标,并有利于改善脑血流情况,且安全性较好。

Objective To investigate the efficacy of citicoline combined with butylphthalide soft capsule on elderly patients with vascular dementia(VD)after cerebral infarction and its effects on cognitive function.Methods Totally 65 elderly patients with VD after cerebral infarction who were admitted to Pingmei Shenma Medical Group General Hospital from January 2018 to December 2019 were selected as the research subjects,and they were divided into control group(32 cases)and observation group(33 cases)according to the random number table method.Patients in control group were treated with citicoline,and patients in observation group were combined with butylphthalide soft capsule on the basis of control group.The efficacy was compared between the two groups after 8 weeks of treatment,and the cognitive function,biochemical indicators and cerebral blood flow status were compared between the two groups before treatment and after 8 weeks of treatment,and the occurrence of adverse reactions during treatment were compared between the two groups.Results After 8 weeks of treatment,the total effective rate of the two groups were compared,P>0.05.The Mini-Mental State Examination(MMSE)scores of the two groups were increased compared with those before treatment,and the scores in observation group were higher than those in control group during the same period(P<0.05).The levels of homocysteine(Hcy)and triglyceride(TG)of the two groups were lower than those before treatment,and the levels of observation group were lower than those of control group during the same period,and the levels of basis artery(BA),anterior cerebral artery(ACA)and vertebral artery(VA)of the two groups were higher than those before treatment,and the above levels in observation group were higher than those in control group during the same period(P<0.05).During the treatment,the adverse reactions of the two groups were compared(P>0.05).Conclusions Citicoline combined with butylphthalide soft capsule has similar efficacy with citicoline alone in the treatment of elderly patients with VD after cerebral infarction,but the combination of medication can improve thecognitive function,adjust biochemical indicators,and help improve cerebral blood flow status,with better safety.