质子泵抑制剂对反流性咽喉炎的治疗效果分析

Therapeutic effect of proton pump inhibitors on reflux pharyngitis

目的探讨质子泵抑制剂对反流性咽喉炎的疗效。方法抽取2018年2月至2021年2月山西晋城大医院收治的反流性咽喉炎患者70例,依据治疗方案分为对照组和观察组,每组35例。对照组给予铝碳酸镁治疗,观察组给予质子泵抑制剂治疗。比较两组临床效果、治疗1 d内食管近端和食管远端pH<4的时间百分比及治疗前后症状评分。结果观察组治疗总有效率高于对照组(χ^(2)=6.331,P<0.05)。治疗1 d内,观察组食管近端、食管远端pH值<4的时间百分比低于对照组(t=4.115、4.352,P<0.05)。治疗后,观察组返酸、烧心、吞咽痛、声音嘶哑评分低于对照组(t=2.601、2.557、2.901、2.855,P<0.05)。结论质子泵抑制剂治疗反流性咽喉炎可改善临床症状、食管近端及食管远端pH值,提高临床疗效。

Objective To investigate the therapeutic effect of proton pump inhibition on reflux pharyngitis.Methods A total of 70 reflux pharyngitis patients who were admitted to Shanxi Jincheng General Hospital from February 2018 to February 2021 were selected,and they were divided into control group and observation group according to the treatment plan,with 35 cases in each group.The control group was treated with hydrotalcite and the observation group was treated with proton pump inhibitor.The clinical effects,the time percentage of pH<4 in the proximal and distal esophagus within 1 day after treatment,and the symptom scores before and after treatment were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group(χ^(2)=6.331,P<0.05),and within 1 day of treatment,the time percentage of pH<4 in the proximal and distal esophagus in the observation group were less than that in the control group(t=4.115,4.352,P<0.05).After treatment,the scores of acid return,heartburn,painful swallowing,and hoarseness in the observation group were lower than those in the control group(t=2.601,2.557,2.901,2.855,P<0.05).Conclusions The treatment of reflux pharyngitis with proton pump inhibitors can improve the clinical symptoms,the pH value of the proximal esophagus and the distal esophagus,and improve the clinical efficacy.