摘要
心血管系统中血栓的形成会严重阻碍心脏和脑部供血,具有发生心梗和脑中风的潜在风险.单一模态的血管造影方法通常无法有效获取血管结构与功能的全面影像学信息,而将静态与动态血管造影相结合能够协同评估血管通畅性并获取血液动力学相关信息,以实现精确诊断和及时有效的治疗.本文首先合成了NaNdF_(4)@NaGdF_(4)核壳纳米颗粒,通过控制壳层厚度调控NIR-Ⅱ荧光、纵向弛豫以及X-射线衰减性质.利用构建的多功能纳米探针对正常鼠进行多模式血管造影,研究发现NIR-Ⅱ荧光造影(FLA)的实时动态性可以快速捕捉小鼠脑部的血管结构,磁共振血管造影(MRA)的无穿透限制和高分辨率可以清晰解析肝脏、心脏和颈动脉等深部组织内的血管,以及CT血管造影在肺部血管造影上具有更高的信噪比.在此基础上,针对颈动脉血管病变及其对脑血管的潜在危害,本研究联合MRA和NIR-ⅡFLA成像实现无创诊断血栓位点,评估脑血流灌注,监测血栓形成和溶栓过程以及疗效评价.研究结果表明多功能造影剂在协同诊断血管病变、动态评估血管病变对邻近器官的血流影响、疗效评价等方面都具有重要应用价值.
作者
Feng Ren
Qiang Yuan
Mengxiao Han
Zhilin Jiang
Hongqin Zhu
Baofeng Yun
Zhen Li
任峰;袁强;韩孟晓;蒋志林;朱红芹;云宝凤;李桢(Center for Molecular Imaging and Nuclear Medicine,State Key Laboratory of Radiation Medicine and Protection,School for Radiological and Interdisciplinary Sciences(RAD-X),Soochow University,Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Suzhou 215123,China;The Second Affiliated Hospital of Soochow University,Suzhou 215004,China)
基金
the National Natural Science Foundation of China(81971671)
the National Key Research and Development Program of China(2018YFA0208800)
the Jiangsu Provincial Key Research and Development Program(BE2019660)
Suzhou Municipal Science and Technology Bureau(N312861019)
the Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University(GZK1202012)
the Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection,the Priority Academic Development Program of Jiangsu Higher Education Institutions(PAPD)。
