心力衰竭患者左心室辅助装置传动系统感染的研究进展

Research progress on left ventricular assist device driveline infection in patients with heart failure

左心室辅助现已成为终末期心力衰竭患者的主要外科治疗策略,在提高心力衰竭患者存活率的同时,常导致一些严重的并发症。心室辅助装置特异性感染,特别是传动系统感染,是心室辅助患者术后常见并发症。生物膜的形成和迁移促进感染向泵腔和血流等更深层次组织的扩散,为后续治疗增加难度,甚至会危及患者生命安全。本文从心室辅助装置传动系统感染的流行病学特征、致病机制、诊断,以及预防和治疗方面的现状进行综述。

Left ventricular assist is now the main surgical treatment strategy for patients with end-stage heart fai-lure,while it improves survival in heart failure patients,it often leads to a number of serious complications.Ventri-cular assist device-specific infection,particularly driveline infection,is a common post-operative complication in ventricular assist patients.Biofilm formation and migration promote the infection spread to deeper tissues such as the pump cavity and blood stream,making subsequent treatment more difficult and even endangering the patient’s life.This article reviews the current status of left ventricular assist device driveline infection in terms of epidemiological characteristics,pathogenic mechanisms,diagnosis,as well as prevention and treatment.