观察帕罗西汀联合小剂量奥氮平治疗抑郁症合并睡眠障碍的治疗效果

Effect of Paroxetine Combined with Low Dose Olanzapine in the Treatment of Depression Complicated with Sleep Disorder

目的:观察帕罗西汀联合小剂量奥氮平治疗抑郁症合并睡眠障碍的治疗效果。方法:选取2019年2月至2020年10月聊城市第四人民医院收治的抑郁症合并睡眠障碍患者84例作为研究对象,按照随机数字表法分为观察组和对照组,每组42例,对照组给予帕罗西汀治疗,观察组在对照组基础上联合给予小剂量奥氮平进行治疗;采用匹兹堡睡眠质量指数量表(Pittsburgh Sleep Quality Index,PSQI)比较2组患者治疗前后睡眠质量的改善情况,采用汉密尔顿抑郁量表(Hamilton Depression Rating Scale,HAMD)评价2组患者治疗前后抑郁症状改善情况,采用SF-36生命质量评分量表(Short Form Health Survey,SF-36)比较2组患者生命质量改善情况,同时比较2组治疗期不同时间段血清Hcy水平变化及不良反应发生率。结果:治疗后,观察组患者PSQI评分优于对照组,其中睡眠潜伏、觉醒次数、清醒时间均低于对照组,睡眠时长高于对照组,2组比较差异有统计学意义(P<0.05);观察组HAMD评分显著低于对照组,SF-36生命质量评分均高于对照组,治疗4周、6周后,观察组患者血清Hcy水平均低于对照组,观察组不良反应发生率显著低于对照组,2组比较差异均有统计学意义(P<0.05)。结论:帕罗西汀联合小剂量奥氮平治疗抑郁症并发睡眠障碍效果显著,能有效增加患者睡眠时长,降低患者觉醒次数,缓解抑郁症状,提高生命质量,安全可靠,值得临床推广使用。

Objective:To study the efficacy of paroxetine combined with low dose olanzapine in the treatment of patients with depression complicated with sleep disorder.Methods:A total of 84 cases from February 2019 to October 2020 in the fourth people′s hospital of liaocheng city with sleep disorder were selected as the research objects,according to the random number table method were divided into observation group and control group,42 cases in each group,control group given paroxetine treatment,the observation group given small dose of olanzapine combined with paroxetine;Pittsburgh Sleep Quality Index(PSQI)was used to compare the improvement of sleep quality beftween 2 groups before and after treatment,and Hamilton Depression Rating Scale(HAMD)was used to evaluate the improvement of depressive between 2 groups,and to compare the improvement of quality of life by using the SF-36 short form health survey(SF-36),compare the changes of serum Hcy levels and the incidence of adverse reactions between 2 groups at different time points during treatment.Results:After treatment,PSQI score of observation group was better than the control group,sleep time more longer than the control group,wake times were lower than the control group,sleep duration was higher than the control group,the difference was statistically significant(Ps<0.05);The HAMD score of the observation group was significantly lower than that of the control group,and the SF-36 quality of life score was significantly higher than that of the control group.After 4 and 6 weeks of treatment,the serum Hcy level of the observation group was lower than that of the control group,and the incidence of adverse reactions in the observation group was significantly lower than that of the control group,with statistical significance(P<0.05).Conclusion:Paroxetine combined with low-dose olanzapine has a significant effect on the treatment of depression complicated with sleep disorder,which can effectively increase the sleep duration of patients,reduce the number of awakenings of patients,relieve depression,improve the quality of life,and is safe and reliable,worthy to promotion in clinical.