阻塞性睡眠呼吸暂停低通气综合征患者血清肿瘤坏死因子-α、白细胞介素-6水平的检测及临床意义

Serum Tumor Necrosis Factor in Patients with Obstructive Sleep Apnea Hypopnea Syndrome-α、Detection of Interleukin-6 Level and Its Clinical Significance

目的:探究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者病情程度与白细胞介素-6(IL-6)与血清肿瘤坏死因子-α(TNF-α)之间的关系,并探究二者与OSAHS相关的心脑血管疾病的关联性。方法:选取2017年3月至2019年7月谷城县人民医院收治的OSAHS患者90例作为研究对象,按照病情程度分为轻度、中度、重度各30例,并选择同期收治的单纯鼾症患者30例作为研究对象,对其血清TNF-α与IL-6的水平进行检测。另外对4组患者心脑血管患病率进行统计。此外对部分中度、重度患者进行经鼻持续气道正压通气(nCPAP)治疗,比较经治疗和未经治疗的患者TNF-α、IL-6的水平变化情况。结果:重度OSAHS患者组的TNF-α与IL-6水平最高,且TNF-α与IL-6水平随患者病情加重而升高,心脑血管疾病发病率也随之升高。另外,接受治疗的OSAHS患者治疗后TNF-α与IL-6水平下降程度显著,未接受治疗者指标水平无明显变化。结论:OSAHS患者病情程度越严重,其TNF-α与IL-6水平越高,提示TNF-α与IL-6水平与OSAHS发病有密切关联,对这2项指标水平进行监测并采取治疗措施,能够有效预防相关心脑血管疾病。

Objective:To investigate the relationship between the severity of obstructive sleep apnea hypopnea syndrome(OSAHS)and interleukin-6(IL-6)and serum tumor necrosis factor-α(TNF-α)And explore the relationship between them and OSAHS related cardiovascular and cerebrovascular diseases.Methods:A total of 90 patients with OSAHS treated in Gucheng County People′s Hospital from March 2017 to July 2019 were selected as the research object,which were divided into 30 cases of mild,moderate and severe according to the degree of illness,and 30 patients with simple snoring treated in the same period were selected as the research object,and their serum TNF was measured-αThe level of IL-6 was detected.In addition,the prevalence of cardiovascular and cerebrovascular diseases in the four groups were statistically analyzed.In addition,some moderate and severe patients were treated with nasal continuous positive airway pressure(nCPAP)to compare TNF between treated and untreated patients-α,changes in the level of IL-6.Results:TNF in patients with severe OSAHS-αAnd IL-6 were the highest,and TNF-αThe level of IL-6 and the incidence rate of cardiovascular and cerebrovascular diseases increase with the aggravation of the patient′s condition.In addition,treated OSAHS patients had TNF after treatment-αand IL-6 decreased significantly,and there was no significant change in the index level of untreated patients.Conclusion:The more serious the condition of OSAHS patients,the higher the TNF-α,the higher the level of IL-6.This suggests TNF-αis closely related to the level of IL-6 and the pathogenesis of OSAHS.Monitoring the level of these two indicators and taking treatment measures can effectively prevent related cardiovascular and cerebrovascular diseases.