创伤脓毒症的免疫和代谢改变

Immune and Metabolic Changes in Traumatic Sepsis

脓毒症是创伤患者死亡的主要原因之一,且目前降低创伤脓毒症死亡率的治疗选择有限。研究认为,代谢途径的紊乱、宿主的缺氧反应以及免疫系统的过度驱动是创伤和脓毒症分子水平上的主要特征,且创伤和脓毒症中免疫失调与代谢过程的改变之间有很强的相互关系,这种免疫代谢紊乱会严重影响患者的预后。本文主要对创伤脓毒症的免疫代谢以及潜在的治疗措施进行综述,以帮助临床更好的认识创伤脓毒症。

Sepsis is one of the main causes of death in trauma patients,and the treatment options for reducing the mortality of trauma sepsis are limited.Studies have shown that metabolic disorders,the host's hypoxic response and excessive drive of the immune system are the main characteristics of trauma and sepsis at the molecular level,and there is a strong correlation between immune disorders and metabolic processes in trauma and sepsis,which seriously affects the prognosis of patients.This article mainly reviews the immune metabolism and potential treatment measures of traumatic sepsis,in order to help clinical better understand traumatic sepsis.