基于5-羟色胺治疗肠易激综合征的中西医研究进展

Research Progress of Traditional Chinese and Western Medicine in the Treatment of Irritable Bowel Syndrome Based on 5-hydroxytryptamine

肠易激综合征(IBS)是一种非胃肠道结构损害和生化异常的胃肠功能紊乱性疾病,其致病机制尚不十分清楚,西医采用多种药物、心理疗法、调节饮食等方式进行治疗,但效果欠佳。近年中医药治疗IBS受到广泛关注,尤其是便秘型与腹泻型,众多研究中针对5-羟色胺(5-HT)信号通路的中医药研究居多,且多获良效,故本文总结中医药基于5-HT治疗IBS的主要机制及成果,为后续研究提供参考。

Irritable bowel syndrome(IBS) is a gastrointestinal disorder with no structural damage and biochemical abnormality,and its pathogenic mechanism is still unclear.Variety of drugs,psychotherapy,diet regulation and other methods have been used by modern medicine to relieve symptoms,but the effect is not satisfactory.In recent years,TCM treatment of IBS has attracted widespread attention,especially for constipation type and diarrhea type.Among the many experiments,most of the traditional Chinese medicine experiments aimed at the 5-HT signaling pathway have achieved good results.Therefore,this paper summarizes the main mechanisms and results of traditional Chinese medicine based on 5-HT in the treatment of IBS,in order to provide a reference for subsequent research.