以巨大足部溃疡为表现的坏疽性脓皮病伴克罗恩病一例报道并文献复习

Pyoderma Gangrenosum with Crohn’s Disease Presenting as a Giant Foot Ulcer:a Case Report and Literature Review

足部溃疡可由多种病因导致,明确其病因对于治疗及预后至关重要。坏疽性脓皮病(PG)是一种少见的嗜中性皮病,且常伴系统性疾病,起病初期表现为炎性丘疹或脓疱,后迅速进展为疼痛性溃疡,易与局部感染性疾病、糖尿病足等混淆,但治疗方案完全不同。因此,临床早期及时诊断至关重要。本文报道了1例以巨大足部溃疡为表现的坏疽性脓皮病伴克罗恩病患者的诊治过程,并进行文献复习,以提高临床医生对此病的认识,减少误诊、误治。

Foot ulcers can be caused by a variety of causes,and identifying the causes is essential for treatment and prognosis.Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that often accompanied by systemic diseases.The initial lesions of pyoderma gangrenosum is inflammatory papules or pustules,which rapidly progress to painful ulcers.Pyoderma gangrenosum are easily confused with local infectious diseases and diabetic feet,but the treatment options are completely different.Therefore,early and rapid diagnosis is crucial.This article reported on the diagnosis and treatment of a patient with pyoderma gangrenosum in association with Crohn’s disease presenting as a giant foot ulcer,and reviewed the literature to improve clinicians’understanding of the disease and reduce misdiagnosis and mistreatment.