外周血炎症指标与非小细胞肺癌EGFR突变的相关性

Correlation between inflammation indexes in peripheral blood and EGFR mutation in non-small cell lung cancer

目的:研究非小细胞肺癌(non-small cell lung cancer,NSCLC)患者表皮生长因子受体(epidermal growth factor receptor,EGFR)基因突变与中性粒细胞与淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)、系统性炎症反应指数(SIRI)三种炎性指标及患者临床病理学特征的相关性。方法:通过回顾性分析的方法比较136例非小细胞肺癌患者EGFR突变型与野生型在各项临床指标、外周血三种免疫细胞及炎症指标上的差异。结果:EGFR野生型患者与突变型患者在性别、吸烟史、病理类型上比较,差异有统计学意义(P<0.05)。EGFR突变型相较于野生型以未吸烟、女性患者、腺癌患者居多。EGFR野生型与突变型在NLR、LMR、SIRI上差异有统计学意义(P<0.05)。EGFR突变型患者治疗前LMR高于野生型患者,EGFR突变型患者治疗前NLR和SIRI低于野生型患者。结论:炎症指标LMR、NLR、SIRI与NSCLC患者EGFR突变具有相关性。LMR对EGFR突变有一定的预测价值,且优于SIRI与NLR。

Objective:To study the correlation between the epidermal growth factor receptor(EGFR)gene mutation in NSCLC patients and the three inflammatory indicators of neutrophil to lymphocyte ratio(NLR),lymphocyte to monocyte ratio(LMR),systemic inflammation response index(SIRI)and the clinical pathological characteristics of patients.Methods:A retrospective analysis was performed to compare the differences of 136 non-small cell lung cancer patients with EGFR mutant and wild type in various clinical indicators,three immune cells in peripheral blood and inflammation indicators.Results:There were significant differences in gender,smoking history,and pathological types between EGFR wild-type patients and mutant patients(P<0.05).Compared with wild-type patients,EGFR mutant patients were mostly non-smokers,female patients and adenocarcinoma patients.The differences between EGFR wild type and mutant type in NLR,LMR and SIRI were statistically significant(P<0.05).The LMR of EGFR mutant patients before treatment was higher than that of wild type patients,and the NLR and SIRI of EGFR mutant patients before treatment were lower than wild type patients.Conclusion:Inflammation indexes LMR,NLR,SIRI are correlated with EGFR mutations in NSCLC patients.LMR has certain predictive value for EGFR mutation and is superior to SIRI and NLR.