造血干细胞移植女性患者的若干问题

Several issues in female patients undergoing hematopoietic stem cell transplant

造血干细胞移植(HSCT)是根治多种造血及非造血系统良恶性疾病的重要方法,应提高临床医生对于女性患者移植前后可能出现的问题的认识,如人乳头瘤样病毒感染、异常子宫出血、早发性卵巢功能不全、生育力保护措施、激素补充治疗与青春期诱导、生殖器移植物抗宿主病等,从而推动HSCT患者的全生命周期医疗管理。

Hematopoietic stem cell transplantation(HSCT)is an important approach to curing a variety of benign and malignant hematopoietic and non-hematopoietic system diseases.As clinicians,we should raise the awareness of potential gynecologic and reproductive health issues that may occur in female patients before and after HSCT,such as human papillomavirus(HPV)infection,abnormal uterine bleeding,premature ovarian insufficiency(POI),fertility preservation,hormone replacement therapy and induction of puberty,and chronic graft-versus-host disease(cGVHD),thus promoting the full life cycle medical management of HSCT patients.