神经递质相关基因与环境交互作用对强迫性障碍的影响研究进展

Research progress on the effect of neurotransmitter related gene and environment interaction on obsessive-compulsive disorder

目的强迫性障碍是一种严重损害人类生活质量的神经精神疾病。已知5-羟色胺转运体、谷氨酸转运体、单胺氧化酶、脑源性神经营养因子等神经递质相关基因参与了强迫性障碍的发生发展,而与强迫性障碍有关的环境证据则包括童年创伤、压力性生活事件等因素,但强迫性障碍的病因及发病机制至今仍未完全阐明。基因-环境交互作用是指基因为适应环境的改变而发生变化,从而导致基因表达差异。基因-环境交互作用已经涉及到包括强迫性障碍在内的许多神经精神疾病的研究中,本文对神经递质相关基因与环境交互作用对强迫性障碍的影响研究进展进行综述,旨在为强迫性障碍的病因学研究及治疗方向等提供证据。

Obsessive-compulsive disorder(OCD)is a neuropsychiatric disorder that seriously damages the quality of human life.It is known that neurotransmitter related genes such as 5-hydroxytryptamine transporter(5-HTT),solute carrier family 1 member 1(SCL1A1),monoamine oxidase gene(MAO)and brain-derived neurotrophic factor(BDNF)are involved in the occurrence and development of OCD.Environmental evidence related to OCD includes childhood trauma,stressful life events and other factors.But the etiology and pathogenesis of OCD have not been fully clarified.Gene-environment(GxE)interaction refers to the changes of genes in response to environmental changes,which results in differences in expression.GxE interaction has been used in studies of many neuropsychiatric disorders including OCD.This paper reviews the research progress of the interaction between neurotransmitter related gene and environment on OCD,aiming to provide evidence for the etiology research and treatment direction of OCD.