小檗碱治疗溃疡性结肠炎研究进展

Research progress of berberine in the treatment of ulcerative colitis

溃疡性结肠炎(UC)是一种原因不明的慢性结肠炎症,其病变主要局限于结肠的黏膜层和黏膜下层。目前,UC的病因尚不完全明确,多数学者认为其发病与遗传、免疫、环境、微生物有关,尚无特效的治疗方法。小檗碱是从中药黄连中提取的主要成分,可用于抗炎、抗微生物、抗肿瘤、降血压、降血糖、降血脂等治疗。研究发现,小檗碱对UC有明确疗效,其作用机制包括抗炎、调节肠道菌群、修复肠黏膜屏障、调节免疫反应等多种途径,但各方面研究尚不完善。本文就小檗碱治疗UC的作用及机制的研究进展加以综述。

Ulcerative colitis(UC)is a chronic colon inflammation of unknown cause,whose lesions are mainly confined to the mucosal and submucosal layers of the colon.At present,the etiology of UC is not completely clear,and most scholars believe that its pathogenesis is related to genetics,immunity,environment and microorganisms,and there is no specific treatment method.Berberine is the main component extracted from Coptis chinensis,which can be used for anti-inflammatory,anti-microbial,anti-tumor,blood pressure reduction,blood sugar reduction blood lipid reduction and other treatments.At present,the study has found that berberine has a clear curative effect on UC,and its action mechanism includes anti-inflammatory,regulating intestinal flora,repairing intestinal mucosal barrier,regulating immune response,and so on,but the research in various aspects is not perfect.This paper reviews the research progress of the effect and mechanism of berberine in the treatment of UC.