肺表面活性物质联合不同通气方式治疗早产儿呼吸窘迫综合征疗效观察

Efficacy Observation of Pulmonary Surfactant Combined with Different Ventilation Methods in Treatment of Respiratory Distress Syndrome in Preterm Infants

目的:探究早产儿呼吸窘迫综合征应用肺表面活性物质(PS)联合不同通气方式治疗的临床效果及治疗安全性。方法:选取2019年4月-2021年4月番禺区妇幼保健院收治的早产儿呼吸窘迫综合征128例,电脑等量随机方式分为试验组和对照组,各64例。试验组给予PS联合加热湿化高流量鼻导管通气,对照组给予PS联合鼻塞式持续性正压通气,分析两组患儿治疗效果、症状改善时间及并发症发生情况。结果:试验组治疗总有效率显著优于对照组,试验组的症状改善时间显著短于对照组,试验组并发症总发生率低于对照组,差异均有统计学意义(P<0.05)。结论:针对早产儿呼吸窘迫综合征,采取PS联合不同通气方式进行治疗,疗效显著,康复效率更高,且治疗后并发症较少,安全性较高。

Objective:To explore the clinical effect and safety of pulmonary surfactant(PS)combined with different ventilation methods in the treatment of respiratory distress syndrome of preterm infants.Methods:A total of 128 premature infants with respiratory distress syndrome were selected from Panyu Maternal and Child Care Service Centre of Guangzhou from April 2019 to April 2021.Using computer equal random method,they were divided into experimental group and control group,with 64 cases in each group.The experimental group was given PS combined with heated humidified high-flow nasal cannula ventilation and the control group was given PS combined with nasal continuous positive pressure ventilation.The treatment effect,improvement of symptoms and complications of children in two groups was analyzed.Results:The overall response rate was significantly better,the improvement time of symptoms was significant shorter and the overall incidence of complications was lower in the experimental group than those in the control group,with statistically significant difference(P<0.05).Conclusion:For premature infants with respiratory distress syndrome,PS combined with different ventilation methods has significant curative effect,higher rehabilitation efficiency,less complications and higher safety.