2015年—2020年温州市新报告HIV/AIDS病例首次CD4^(+)T淋巴细胞检测结果分析

Analysis of the first CD4^(+)T lymphocytes test results of newly reported HIV/AIDS cases in Wenzhou City during 2015-2020

目的了解温州市2015年—2020年新报告HIV/AIDS病例首次CD4;T淋巴细胞(简称CD4细胞)水平,评估免疫状况和疾病进展,为艾滋病防治提供科学依据。方法从艾滋病综合防治数据信息管理系统获得温州市2015年—2020年新报告HIV/AIDS病例信息,对一般人口学特征和首次CD4细胞检测结果进行统计分析。结果2015年—2020年温州市新报告HIV/AIDS病例完成首次CD4细胞检测比例为95.0%,该比例历年无变化(χ^(2)_(趋势)=1.745,P>0.05)。首次CD4检测与确证时间间隔≤14 d占77.9%,构成比呈现逐年上升趋势(χ^(2)_(趋势)=57.096,P<0.001)。首次CD4细胞<200个/μl占36.2%,构成比呈现逐年上升趋势(χ^(2)_(趋势)=4.948,P<0.05)。男性(95%CI:1.292~1.903),40岁~59岁年龄组(95%CI:1.766~4.632)、60岁及以上年龄组(95%CI:1.395~3.760),医疗机构检测发现(95%CI:1.637~2.342)的HIV/AIDS易发生首次CD4细胞<200个/μl的情况。结论温州市近几年新报告HIV/AIDS病例首次CD4细胞<200个/μl比例较高,且呈现上升趋势,应加强HIV检测覆盖面,尽早发现HIV感染者并启动抗病毒治疗。

Objective To understand the level of the first CD4^(+)T lymphocytes of newly reported HIV/AIDS cases in Wenzhou City during 2015-2020,assess the immune status and disease progression,and provide scientific basis for AIDS prevention and control.Methods Data of newly reported HIV infected persons were collected from HIV/AIDS Prevention and Control Information Management System.General demographic characteristics and the first CD4^(+)T lymphocytes were analyzed.Results From2015 to 2020,the proportion of newly reported HIV/AIDS cases in Wenzhou who completed the first CD4^(+)T cell test was95.0%,and this proportion has not changed over the years(χ^(2)_(tendency)=1.745,P>0.05).The time interval between the first CD4^(+)T test and confirmation less than or equal to 14 days accounted for 77.9%,and the proportion showed an upward trend year by year(χ^(2)_(tendency)=57.096,P<0.001).The first CD4^(+)T less than 200 cell perμl accounted for 36.2%,and the proportion showed an upward trend year by year(χ^(2)=4.948,P<0.05).The initial CD4^(+)T cell count test result less than 200 cells perμl was more likely to occur for the patients of male(95%CI:1.292-1.903)in 40-59 age group(95%CI:1.766-4.632),60 and above age group(95%CI:1.395-3.760),and the cases diagnosed from medical institutions(95%CI:1.637-2.342).Conclusion In recent years,the proportion of newly reported HIV/AIDS cases in Wenzhou City for the first CD4^(+)T less than 200 cell perμl is high,and it is showing an upward trend.We should strengthen the coverage of HIV testing,detect HIV-infected persons as soon as possible and initiate antiviral treatment.