大黄素对肝脏疾病的防治作用与安全性研究进展

Advances in Research on the Preventive and Therapeutic Effects and Safety of Emodin on Liver Diseases

大黄素是一种蒽醌类衍生物,是从何首乌、大黄等中药中提取得到的主要活性单体。现代药理研究证明,大黄素具有广泛的药理活性,其中对于肝脏疾病如肝脏炎症、肝癌、肝纤维化以及对各类肝损伤等均有良好的防治作用。然而在研究过程中,大黄素对肝细胞的潜在毒性作用也逐渐显现。因此,本研究综合近年来大黄素在肝脏上的研究,对其药理作用、机制及安全性进行综述,旨在为进一步安全有效地应用大黄素提供参考依据。

Emodin is an anthraquinone derivative, which is the main active monomer extracted from rhubarb. Modern pharmacological studies have proved that emodin has a wide range of pharmacological activities, including good effects for prevention and treatment of liver diseases such as liver inflammation, liver cancer, liver fibrosis and various types of liver injury, liver failure, fatty liver and so on. However, in the course of research, the potential toxicity of emodin on hepatocytes has also gradually been discovered. Therefore, this article reviews the progress in research on the pharmacological action, mechanism and safety of emodin in the prevention and treatment of liver diseases in recent years in order to provide reference for further, safe and effective application of emodin.