晚期糖基化终末产物受体参与病理性疼痛机制的研究进展

Recent advance in mechanism of advanced glycation end-product receptors in pathological pain

晚期糖基化终末产物受体(RAGE)是一种新的模式识别受体,在免疫细胞和神经细胞均有表达。研究显示,RAGE的异常激活参与病理性疼痛的发病机制,通过抑制RAGE激活可预防或缓解动物的病理性疼痛症状。本文围绕近年来RAGE参与病理性疼痛机制的研究进展进行综述,旨在探讨RAGE作为病理性疼痛治疗靶点的可能性以及面临的问题。

The advanced glycation end-products(RAGE)receptors are a kind of new pattern-recognition receptors,which express in both immune cells and nerve cells.New studies have shown that aberrant activation of RAGE involves in pathological pain,and inhibiting the activation of RAGE can prevent or alleviate pathological pain in animals.In this paper,we review the recent literatures in the involvement of RAGE in pathological pain,and discuss the possibility and challenges of RAGE as a therapeutic target for pathological pain.