糖尿病周围神经病与认知障碍的研究进展

Research progress of diabetic peripheral neuropathy and cognitive impairment

糖尿病周围神经病与认知障碍作为糖尿病的神经系统并发症常共存于糖尿病个体中,严重影响患者的生活质量。二者分别表现为糖尿病的周围和中枢神经系统病变,传统观点认为二者为独立的疾病。目前越来越多的证据表明,二者存在显著的相关性,病理生理机制有许多共同之处,且存在许多共同的生物学标志物。现对糖尿病患者发生周围神经及认知损伤的临床表现及电生理表现、病理生理机制、病理变化、生物学标志物进行综述,以进一步阐述二者之间的相互联系。

Diabetic peripheral neuropathy and cognitive impairment,as the neurological complications of diabetes,often occur in diabetic individuals at the same time,and seriously affect the quality of life of diabetic patients.The two manifested as diabetic peripheral and central nervous system diseases respectively.The traditional view is that the two are independent diseases.At present,more and more evidences show that there is a significant correlation between diabetic peripheral neuropathy and cognitive impairment.The pathophysiological mechanisms of the two have many things in common,and the two have many common biological markers.This article reviews the clinical manifestations and electrophysiological manifestations,pathophysiological mechanisms,pathological changes,and biological markers of peripheral nerve and cognitive impairment in diabetic patients to further illustrate the relationship between the two.