氨甲环酸联合A型肉毒毒素导入皮肤改善色素沉着的临床研究

Clinical study on tranexamic acid combined with botulinum toxin type A in the improvement of pigmentation

目的探讨氨甲环酸联合A型肉毒毒素导入皮肤改善色素沉着的临床疗效。方法 2020年1月—12月,河北工程大学附属医院整形外科将54例色素沉着患者,随机分为3组,对照组(15例):仅嘱患者日常防晒保湿;A组(20例):导入氨甲环酸治疗色素沉着;B组(19例):导入氨甲环酸+A型肉毒毒素治疗色素沉着。治疗后随访2个月,观察各组治疗效果并进行疗效及满意度评价。结果 A组和B组局部色素沉着较对照组颜色变淡且面积相对减小,差异有统计学意义(P<0.05)。A、B两组比较,B组较A组色素沉着颜色变浅更为明显,且颜色与周围正常组织更为接近,差异有统计学意义(P<0.05)。A组的满意度率为90.00%(18/20),B组的满意率为100%(19/19)。结论氨甲环酸联合A型肉毒毒素导入皮肤改善色素沉着效果良好,不良反应较小,值得临床推广应用。

Objective To explore the clinical efficacy of tranexamic acid(TCA) combined with botulinum toxin type A in the improvement of pigmentation. Methods From January to December 2020, 54 patients with pigmentation were selected and randomly divided into 3 groups. In control group, daily sunscreen and moisturizer was performed in 15 patients. The TCA was imported into 20 patients in group A. The TCA combined with botulinum toxin type A was performed in 19 patients to treat pigmentation in group B. Two months at the end of treatment, the efficacy and satisfaction were observed and evaluated. Results After treatment, local pigmentation in group A and B was lighter in color and smaller in area than control group, the difference was statistically significant(P<0.05). The results of comparison between group A and B showed that the pigmentation color in group B was lighter than that in group A, and the color was similar to surrounding normal tissue. The difference was statistically significant(P<0.05). The satisfaction rate of group A was 90.00%(18/20) and group B was 100%(19/19). Conclusion The efficacy of TCA combined with botulinum toxin type A in the improvement of pigmentation is good.The adverse reactions are less. It should be considerable for clinical promotion and application.