基于ZIF-67衍生的C-N-Co(3)O_(4)多孔碳电化学传感器检测对乙酰氨基酚

Electrochemical sensor for the determination of acetaminophen based on ZIF-67 derived C-N-Co(3)O_(4) porous carbon

以金属有机骨架材料ZIF-67为前驱体,在N;保护下碳化热解形成C-N-Co(3)O_(4)多孔碳材料。利用X射线粉末衍射仪(XRD)、透射电镜(TEM)、N;物理吸附仪对材料的形貌、比表面积及孔分布进行表征。由于该材料具有较大的比表面积及优良的导电性,将C-N-Co(3)O_(4)固定到玻碳电极表面(GCE)构建了电化学传感器,用于检测对乙酰氨基酚(AP)。采用循环伏安、电化学交流阻抗法和差分脉冲伏安法研究传感器的电化学性能。结果表明,在最优实验条件下,C-N-Co(3)O_(4)修饰传感器的峰电流与AP溶液浓度在2.0×10^(-4)~1.5 mmol/L呈线性关系,检出限为30 nmol/L。该传感器用于西药样品中AP检测,加标回收率为94.1%~103.8%。

A porous carbon C-N-Co(3)O_(4)was prepared by carbonizing zeolitic imidazolate framework-67(ZIF-67).The resulting material was characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM) and nitrogen adsorption isotherms.A sensitive and stable electrochemical sensor was constructed based on C-N-Co(3)O_(4)as a sensing platform.The C-N-Co(3)O_(4)modified sensor exhibited an excellent conductivity with a linear range of 2.0×10^(-4)-1.5 mmol/L and a low detection limit of 30 nmol/L for detecting of acetaminophen(AP).A satisfactory selectivity was observed towards AP detection in the coexisting of interfering substances.The sensor was applied to detect AP in potion samples with the recovery rates of 94.1%-103.8%.