临床药师参与下对华法林抗凝过度的房颤患者开展抗凝管理的成效分析

Effectiveness Analysis of Anticoagulant Management on Patients with Atrial Fibrillation and Over-anticoagulation with Warfarin

目的:分析房颤患者华法林抗凝过度的可能原因,并积极开展抗凝管理,为华法林合理使用提供参考。方法:选取医院2017年1月-2020年7月收治的华法林过度抗凝房颤患者治疗资料,分析临床药师参与的抗凝管理模式对房颤患者华法林抗凝治疗的影响。结果:房颤患者华法林抗凝过度可能与药物相互作用、合并疾病影响、剂量调整和国际标准化比值(international normalized ratio,INR)监测不规范等有关。临床药师参与华法林抗凝治疗,并实施药学监护发挥了积极作用。结论:临床药师参与临床对房颤患者抗凝管理,有助于提高患者抗凝治疗的依从性和安全性。

Objective: To analyze the possible causes of over-anticoagulation with warfarin in patients with atrial fibrillation and actively carry out anticoagulation management so as to provide reference for rational usage of warfarin.Methods: Data of excessive anticoagulant treatment of warfarin in patients with atrial fibrillation(AF) admitted to our hospital from January 2017 to July 2020 were selected to analyze the influence of anticoagulant management mode with clinical pharmacists’ participation on warfarin anticoagulant treatment in patients with AF. Results: Excessive anticoagulation of warfarin in patients with AF might be related to drug interactions, complication, dose adjustment,non-standard international normalized ratio(INR) monitoring, etc. Clinical pharmacists participated in warfarin anticoagulant treatment and implemented pharmaceutical care played a positive role. Conclusion: Clinical pharmacists participate in clinical anticoagulant management of patients with AF, which is helpful to improve the patients’ compliance and safety of anticoagulant therapy.