泰万菌素对猪繁殖与呼吸综合征的防控效果试验

Evaluation of Prevention and Control Effect of Tylvalosin on PRRS

为检验泰万菌素对猪繁殖与呼吸综合征(PRRS)的防控效果,用2种泰万菌素制品(A、B)和黄芪多糖饲喂妊娠母猪,通过统计临床生产指标、母猪和仔猪抗体水平、病毒检出率以及细胞因子IL-2、IFN-γ表达水平等,综合评价泰万菌素的PRRS防控效果。结果显示:泰万菌素的PRRS防控效果明显优于黄芪多糖,其中泰万菌素A、B组母猪的产健仔率由试验前的84.98%分别提高到94.44%、91.89%,产弱胎、死胎或木乃伊胎率相应降低;泰万菌素A、B组母猪流产率降低,体内抗体下降速率减缓,所产仔猪抗体稳定性和整齐度提高,母猪血液中的PRRS病原检出率和浓度降低,IL-2表达水平下降,IFN-γ表达水平上升。结果表明,泰万菌素可降低妊娠母猪因PRRS造成的繁殖障碍率,同时可通过调控细胞因子水平增强机体免疫力,从而起到防控PRRS的作用。本研究为PRRS防控提供了一种新思路。

In order to evaluate the prevention and control efect of tylvalosin on porcine reproductive and respiratory syndrome(PRRS),pregnant sows were fed with two kinds of tylvalosin products(A and B)and astragalus polysaccharide to comprehensively evaluate the efect of tylvalosin by means of clinical production indicators,antibody levels in sows and piglets,virus detection rate and expression level of cytokines IL-2 and IFN-γ.The results showed that,compared to astragalus polysaccharide,tylvalosin was more efective for PRRS,for groups tylvalosin A and B,the healthy litter rates of sows were increased from 84.98%(prior to evaluation)to 94.44%and 91.89%,respectively,and the rates of weak fetus,stillbirth or mummified fetus decreased accordingly;the abortion rate decreased,the decline rate of antibody level in vivo slowed down,the stability and uniformity of antibody level in their piglets increased,the detection rate and concentration of PRRS pathogens in sows’blood decreased,the expression level of IL-2 decreased,and that of IFN-γincreased.In conclusion,tylvalosin could reduce the reproductive disorder caused by PRRS in pregnant sows,enhance immunity by regulating the level of cytokines,and consequently prevent and control PRRS.A new idea was thereby provided by the study for PRRS prevention and control.