基于网络药理学方法初探葛花解酒涤脂汤抗酒精性脂肪肝作用

Study on anti-alcoholic fatty liver effect of Gehua Jiejiu Dizhi Decoction based on network pharmacology

目的基于网络药理学方法初探葛花解酒涤脂汤(GJDD)治疗酒精性脂肪肝(AFLD)的潜在活性化合物及其可能的作用靶点。方法建立GJDD药物-化合物数据集、化合物-靶点数据集、AFLD靶点数据集,构建GJDD抗AFLD的“中药-化合物-靶点”交互网络图,并通过Cytoscape软件对网络进行分析,初探GJDD抗AFLD的潜在活性化合物及其可能的作用靶点。结果GJDD可能作用于PIK3CA、PIK3R1、MAPK1、APP等靶点,并通过炎症相关信号通路、激素相关通路、凋亡相关信号通路等多条通路达到其治疗目的。结论该研究通过网络药理学再次肯定了GJDD治疗AFLD的有效性,为进一步研究AFLD发生及GJDD干预作用机制提供重要指导。

Objective To explore the potential active compounds and effect targets of Gehua Jiejiu Dizhi Decoction(GJDD)for treatment of alcoholic fatty liver disease(AFLD)based on the network pharmacology.Methods The GJDD drug-compound data set,compound-target data set and AFLD target data set were established,the"TCM-compound-target"interactive network diagram of GJDD anti-AFLD was constructed,and the network was analyzed through Cytoscape to explore GJDD potentially active compounds of anti-AFLD and their possible targets.Results GJDD might act on PIK3CA,PIK3R1,MAPK1,APP and other targets,and achieve its therapeutic purpose through multiple pathways such as inflammation-related signaling pathways,hormone-related pathways,and apoptosis-related signaling pathways.Conclusion Through network pharmacology,this study confirms the effectiveness of GJDD in the treatment of AFLD,and provides important guidance for improving the occurrence of AFLD and the research on the intervention mechanism of GJDD.