氟苯尼考中间体氟代物含量的检测方法

The Detection Method of Intermediate Fluorgeneration Content

氟苯尼考为酰胺醇类广谱抗菌类兽药产品,用于动物因细菌引起的全身部位感染的治疗。由于其在生产过程的中间体氟代物的含量将直接影响到氟苯尼考的含量与杂质,直接影响氟苯尼考的疗效与生物利用度。选择一种能快速检测氟代物含量、准确度高的检测方法。根据研究表明采用该液相色谱方法能快速准确地得出结果,可用于氟苯尼考中间体氟代物含量过程质量控制检测方法。

Florfenicol is an amide alcohol broad-spectrum antibacterial veterinary drug product,which is used for the treatment of systemic infection caused by bacteria.The content of fluorinated intermediate in the production process will directly affect the content and impurities of florfenicol,and directly affect the eff icacy and bioavailability of florfenicol.In this paper,a rapid and accurate detection method is selected.According to the research,the results can be obtained quickly and accurately by this liquid chromatography method,which can be used for the process quality control and detection of fluorides in florfenicol intermediates.