沙库巴曲缬沙坦对左心室射血分数保留心力衰竭老年患者左室重构及心功能的影响

Effects of salkubatroxartan on left ventricular remodeling and cardiac function in elderly patients with heart failure with left ventricular ejection fraction preservation

目的探讨沙库巴曲缬沙坦对左心室射血分数保留心力衰竭老年患者左室重构及心功能的影响。方法选取88例左心室射血分数保留心力衰竭老年患者,随机将其分为观察组和对照组,各44例。对照组予以缬沙坦治疗,观察组予以沙库巴曲缬沙坦治疗,均连续治疗3个月。比较两组患者左室重构、心功能、炎症因子等指标。结果观察组患者治疗后舒张早期血流峰速度减速时间(DT)、左心房容积指数(LAVI)、左心室质量指数(LVMI)、舒张早期二尖瓣血流速度/舒张早期二尖瓣环运动速度(E/E')、左心室舒张末期内径(LVEDD)、N末端脑钠肽前体(NT-proBNP),超敏C反应蛋白(hs-CRP)、白介素-33(IL-33)、肿瘤坏死因子-α(TNF-α)均明显低于对照组(t分别=7.39、2.08、5.14、3.14、-4.29、-3.87、4.51、7.54、3.96,P均<0.05);治疗后舒张早期二尖瓣血流速度/舒张晚期二尖瓣血流速度(E/A)、左心室短轴缩短率(LVFS)、左心室射血分数(LVEF)、6 min步行距离明显高于对照组(t分别=6.95、5.14、11.29、6.82,P均<0.05);两组不良反应发生率比较,差异无统计学意义(χ^(2) =0.51,P>0.05)。结论沙库巴曲缬沙坦能有效改善左心室射血分数保留心力衰竭老年患者左室重构及心功能,并抑制炎症因子水平的表达。

Objective To investigate the effect of salkubatroxartan on left ventricular remodeling and cardiac function in elderly patients with heart failure with left ventricular ejection fraction preservation.Methods Totally 88 elderly patients with left ventricular ejection fraction preserved heart failure were randomly divided into observation group and control group,with 44 cases in each group.The control group was treated with valsartan and the observation group was treated with salkubatrol valsartan for 3 months.The indexes of left ventricular remodeling,cardiac function and inflammatory factors were compared between the two groups.Results After treatment,the peak velocity deceleration time(DT),left atrial volume index(LAVI)and left ventricular mass index(LVMI),the ratio of early diastolic mitral flow velocity to early diastolic mitral annular motion velocity(E/E'),left ventricular end diastolic transit(LVEDD),N-terminal pro brain natriuretic peptide(NT-proBNP),high-sensitivity C-reactive protein(hs-CRP),interleukin-33(IL-33),tumor necrosis factor-α(TNF-α)of the observation group were lower than those of the control group(t=7.39,2.08,5.14,3.14,-4.29,-3.87,4.51,7.54,3.96,P<0.05).After treatment,the early diastolic mitral flow velocity/late diastolic mitral flow velocity(E/A),left ventricular fractional shortening(LVFS),left ventricular ejection fraction(LVEF)and 6-minute walking distance of the observation group were higher than those of control group(t=6.95,5.14,11.29,6.82,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2) =0.51,P>0.05).Conclusion Salkubatroxartan can effectively improve left ventricular ejection fraction,preserve left ventricular remodeling and cardiac function in elderly patients with heart failure,and inhibit the expression of inflammatory factors.