育龄期女性不孕症与代谢综合征相关指标

Relationship between the metabolic syndrome related indicators of women of childbearing age and their infertility

目的:探讨代谢综合征相关指标与女性不孕症相关性。方法:选择2018年4月-2020年2月本院就诊的代谢综合征患者74例为观察组,同期健康体检正常女性56例为对照组。均完成代谢综合征相关指标,观察组根据是否发生不孕症分为不孕组与非不孕组,对不孕症发生的可能因素行多因素logistic分析,分析与代谢综合征相关指标的相关性。结果:观察组收缩压(SBP)、舒张压(DBP)、腰围(WC)、空腹血糖(FBG)水平均高于对照组,高密度脂蛋白(HDL-C)水平低于对照组(P<0.05);观察组不孕发生率为33.8%,不孕组SBP、DBP、FBG水平均高于非不孕组,HDL-C水平低于非不孕组(P<0.05)。多因素分析,不孕症发生与否其SBP、DBP、HDL-C、FBG水平存在差异(P<0.05);Pearson相关性分析表明,不孕症发生率与WC、三酰甘油(TC)无相关性(P>0.05),与SBP、DBP、FBG呈正相关性(P<0.05),与HDL-C呈负相关性(P<0.05)。结论:代谢综合征患者常伴有血糖、血脂及血压异常,不孕症发生与这些指标存在相关性,其中与SBP、DBP、FBG正相关,与HDL-C负相关。

Objective:To explore the relationship between metabolic syndrome related indicators of women of childbearing age and their infertility.Methods:A total of 74 childbearing age women with metabolic syndrome were selected in observation group,and 56 healthy women were selected in control group from April 2018 to February 2020.The related indicators of metabolic syndrome of the women in the two groups were detected.The women in the observation group were divided into group A(women with infertility)and group B(women without infertility).The possible factors of infertility of the women were analyzed by multivariate Logistic analysis.The relationship between metabolic syndrome related indicators of women and their infertility was analyzed.Results:The values of systolic blood pressure(SBP),diastolic blood pressure(DBP),and waist circumference(WC),and the fasting blood glucose(FBG)level of the women in the observation group were significantly higher than those of the women in the control group,while the level of high-density lipoprotein(HDL-C)of the women in the observation group was significantly lower(P<0.05).The incidence of infertility of the women in the observation group was 33.8%.The values of SBP,DBP and the FBG level in group A were significantly higher than those of the women in group B,but the level of HDL-C of the women in group A was significantly lower(P<0.05).Multifactor analysis showed that the rate of infertility of the women had significant different among the women with different values of SBP and DBP,or among the women with different levels of HDL-C and FBG(P<0.05).Pearson correlation analysis showed that there was no correlation between the incidence of infertility of the women and their values of WC and TC(P>0.05).The values of WC and TC of the infertility women were positively correlated with their SBP and DBP values,and their FBG level(P<0.05),while which were negatively correlated with their HDL-C level(P<0.05).Conclusion:The women with metabolic syndrome patients are often have abnormal blood glucose and blood lipid levels,and abnormal blood pressure value,which are correlated with their incidence of infertility.The infertility rate of the women with metabolic syndrome is positively correlated with their SBP and DBP values,and their FBG level,while is negatively correlated with their HDL-C level.