消化道微生物与胰腺癌相关性研究

Mechanisms of digestive tract microbiomes affecting the incidence of pancreatic cancer

胰腺癌是世界上最致命的恶性肿瘤之一,目前胰腺癌的病因尚未完全明确,是肿瘤研究领域的一个热点。近年来大量研究表明,胰腺癌的发生发展可能与消化道微生物群密切相关。近期研究发现,某些口腔、胃肠道和胰腺内的细菌、真菌和肝细胞病毒可能在胰腺癌发病机制中发挥潜在的病因作用。具体机制主要包括维持炎症、调节免疫系统、影响新陈代谢和改变肿瘤的微环境。在这篇综述中,探讨了消化道微生物与胰腺癌之间的联系,探讨微生物群在胰腺癌诊断和治疗中的潜在应用,并深入了解消化道微生物群在胰腺癌中的作用。

Pancreatic cancer is one of the most lethal malignancies. At present, the etiology of pancreatic cancer is not completely clear, and it is a hot spot in the field of tumor research. A large number of recent studies have shown that the occurrence and development of pancreatic cancer may be intimately connected with the microbiomes of the digestive tract. Recent studies have found that certain oral, gastrointestinal and pancreatic bacteria, fungi and hepatocellular viruses may play potential etiological roles in the pathogenesis of pancreatic cancer. Concrete mechanisms include maintaining inflammation, regulating the immune system, affecting metabolism, and altering the tumor microenvironment. In this review, we explore the links between digestive tract microbiomes and pancreatic cancer, discuss potential diagnostic and therapeutic applications of microbiomes, and generate insight into the role of digestive tract microbiomes in pancreatic cancer.