结肠癌肝转移应用聚乙烯醇载药微球介入栓塞的临床效果

Clinical effect of embolization with polyvinyl alcohol-loaded microspheres for liver metastases from colon cancer

目的 探讨结肠癌肝转移应用聚乙烯醇载药微球介入栓塞的临床效果。方法 研究对象选取2020年1月到2021年1月间眉山市中医医院收治的结肠癌肝转移患者86例。采用随机数字法将其分为对照组和试验组,各43例。对照组采用传统栓塞治疗(碘化油+表柔比星)治疗,试验组采用新型栓塞治疗(聚乙烯醇载药微球+表柔比星)治疗。比较两组治疗后肝功能水平、肿瘤坏死率、临床疗效、不良反应。结果试验组疾病缓解率、疾病控制率分别为79.07%(34/43)、95.35%(41/43)。对照组疾病缓解率、疾病控制率分别为51.16%(22/43)、88.37%(38/43)。试验组疾病缓解率、肿瘤坏死率显著高于对照组,差异均具有统计学意义(P<0.05)。试验组患者ALT、AST、Alb水平分别为(35.39±7.65)U/L、(36.87±7.68)U/L、(38.21±7.54)g/L。对照组患者ALT、AST、Alb水平分别为(48.14±10.36)U/L、(50.24±11.54)U/L、(31.24±6.47)g/L。试验组患者ALT、AST水平均显著低于对照组,试验组患者Alb水平显著高于对照组,差异均具有统计学意义(P<0.05)。试验组消化道反应、腹痛、发热的发生率均显著低于对照组,差异均具有统计学意义(P<0.05)。结论 结肠癌肝转移应用聚乙烯醇载药微球介入栓塞,可有效提高肿瘤坏死率、疾病缓解率,保护肝脏功能,降低不良反应。

Objective To investigate the clinical effect of embolization with polyvinyl alcohol-loaded microspheres for liver metastases from colon cancer.Methods Eighty-six patients with liver metastases from colon cancer who were admitted from January 2020 to January 2021 were selected as the study subjects.They were divided into a control group and an experimental group by random number method,each with 43 cases.The control group was treated with traditional embolization therapy(lipiodol in combination with epirubicin),and the experimental group was treated with new embolization therapy(polyvinyl alcohol drug-loaded microspheres in combination with epirubicin).Liver function levels,tumor necrosis rate,clinical efficacy,and adverse reactions were compared between these two groups of patients after treatment.Results The disease remission rate and disease control rate of the experimental group were 79.07%(34/43)and95.35%(41/43),respectively.The disease remission rate and disease control rate of the control group were 51.16%(22/43)and 88.37%(38/43),respectively.The disease remission rate and tumor necrosis rate of the experimental group were significantly higher than those of the control group(P<0.05).The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and albumin(Alb)in the experimental group were(35.39±7.65)U/L,(36.87±7.68)U/L,and(38.21±7.54)g/L,respectively.The levels of ALT,AST and Alb in the control group were(48.14±10.36)U/L,(50.24±11.54)U/L,and(31.24±6.47)g/L,respectively.The levels of ALT and AST in the test group were significantly lower than those in the control group,and the Alb levels in the test group were significantly higher than those in the control group(P<0.05).The incidence of gastrointestinal reactions,abdominal pain,and fever in the test group were significantly lower than those in the control group(P<0.05).Conclusion Interventional embolization with polyvinyl alcohol-loaded microspheres for liver metastases from colon cancer can effectively increase tumor necrosis rate,disease remission rate,protect liver function,and reduce adverse reactions.