艾滋病合并恶性肿瘤住院患者疾病谱分析

Spectrum analysis of malignant tumor diseases in hospitalized AIDS patients

目的 探讨南宁市第四人民医院艾滋病合并恶性肿瘤住院患者疾病谱,为广西艾滋病合并恶性肿瘤流行病学研究和治疗提供科学数据。方法 收集2014年1月至2019年12月年南宁市第四人民医院收治的12 711例艾滋病住院患者临床资料,总结分析艾滋病住院患者合并恶性肿瘤种类和分布,年龄分布,6年间发病率变化情况。结果 12 711例艾滋病患者中,共合并恶性肿瘤755例,占总人数5.94%,包括艾滋病相关肿瘤(ADCs)236例(1.86%)和非艾滋病定义性肿瘤(NADCs)519例(4.08%),肿瘤类型达64种。NADCs排前5位是消化道、呼吸道、女性生殖道、泌尿系、皮肤组织等部位的恶性肿瘤。男性艾滋病患者合并恶性肿瘤发病率显著高于女性患者(χ^(2)=11.891,P<0.01),男性艾滋病患者患淋巴瘤、肝癌构成比显著高于女性(χ^(2)=13.594、11.160,均P<0.01),女性患者患结直肠癌显著高于男性(χ^(2)=7.951,P<0.01)。6年间每年艾滋病住院患者合并恶性肿瘤发病率以及合并淋巴瘤、卡波西肉瘤、呼吸道恶性肿瘤、消化道恶性肿瘤发病率相近。结论 本院HIV/AIDS患者合并恶性肿瘤发病率较高,疾病谱以NADCs为主,消化系统恶性肿瘤最常见,男性更易患淋巴瘤、肝癌,女性更易患者结直肠癌,6年间合并恶性肿瘤谱变化不大。

Objective To explore the spectrum of malignant tumor in AIDS patients in our hospital,and to provide scientific data for epidemiological study and treatment of AIDS in Guangxi.Method the clinical data of 12711 AIDS patients admitted to Nanning Fourth People’s Hospital from January 2014 to December 2019 were collected and analyzed.The types and distribution,age distribution and incidence rate of six cases of AIDS in hospital were analyzed.Result among the 12 711 AIDS patients,755 cases developed malignant tumors,accounting for 5.94% of the total number,including 236 cases (1.86%) AIDS related tumors (ADCs) and 519 cases (4.08%) non-HIV defined tumors (NADCs),with 64 tumor types.The top five nadcs are malignant tumors of digestive tract,respiratory tract,female reproductive tract,urinary system and skin system.The incidence rate of malignant tumor in male patients with AIDS was significantly higher than that in female patients (χ^(2)=11.891,P<0.01).The proportion of lymphoma and liver cancer in male AIDS patients was significantly higher than that in females (χ^(2)=13.594,11.160,P<0.01),and the incidence of colorectal cancer in female patients was significantly higher than that in male patients (χ^(2)=7.951,P<0.01).The incidence rate of malignant tumor in AIDS patients was six years,and was similar to that of lymphoma,Posey’s sarcoma,respiratory tract malignant tumor and digestive tract malignant tumor.Conclusion The incidence rate of malignant tumor is higher in HIV/AIDS patients,the disease spectrum is different.Non-HIV defined cancer is the most common.The most common malignant tumor is digestive system.Men are more likely to have lymphoma and liver cancer and women are more likely to have colorectal cancer.There was a little change in the tumor spectrum over the6 year period.