4种血清肿瘤标志物及粪便隐血的结合检测在Dukes B期结肠癌诊断中的应用

Application of combined detection of 4 serum tumor markers and fecal occult blood in the diagnosis of Dukes stage B colon cancer

目的:评价在Dukes B期结肠癌4种肿瘤标志物联合粪便隐血检测的临床诊断价值。方法:选取本院2018-04~2020-03收治Dukes B期结肠癌、结肠息肉患者各40例以及40例健康体检者(对照组)作为检测对象。检测3组受检者CEA、AFP、CA125、CA199水平以及进行粪便隐血检测。对比3组受检者检测结果。结果:结肠癌组患者4种血清肿瘤标志物与粪便隐血相比对照组均明显更高(P<0.05);与结肠癌组患者粪便隐血、CA125、CA199以及CEA相比结肠息肉患者明显更高(P<0.05);结肠癌组患者CA125、CA199、CEA以及粪便隐血阳性率相比结肠息肉患者、对照组受检者均显著更高(P<0.05);结肠癌组患者各指标联合诊断的阳性率相比结肠息肉患者、对照组受检者均显著更高(P<0.05);通过Logistic回归分析显示,粪便隐血阳性、CA125、CEA、CA199以及AFP均作为结肠癌的高危因素(P<0.05);通过二项分类Logistic回归分析显示CA125、粪便隐血指标水平升高可作为结肠癌发生的独立危险因素(P<0.05)。结论:针对Dukes B期结肠癌患者的临床诊断中,CA125、CEA、CA199以及AFP等4种血清肿瘤标志物联合粪便隐血试验诊断阳性率较高。

Objective:To investigate the clinical value of 4 tumor markers combined with fecal occult blood test in the diagnosis of Dukes stage B colon cancer.Methods:A total of 40 patients with Dukes stage B colon cancer and 40 patients with colonic polyps admitted to the First Affiliated Hospital of Jiamusi University from April 2018 to March 2020 were selected for the study,and 40 healthy subjects during the same period were selected as the control group.CEA,AFP,CA125,CA199 levels were detected,and fecal occult blood was detected.The results of the three groups were compared.Results:The results of 4 serum tumor markers and fecal occult blood in colon cancer group were higher than those in control group,and the differences were statistically significant(P<0.05).Compared with colon cancer group,the levels of fecal occult blood,CA125,CA199 and CEA in colon polyp group were significantly higher,with statistical significance(P<0.05).The levels of CA125,CA199 and CEA and the positive rate of fecal occult blood in colon cancer group were significantly higher than those in colon polyp group and control group,and the differences were statistically significant(P<0.05).The positive rate of colon cancer group was significantly higher than that of colonic polyp group and control group,with statistical significance(P<0.05).Logistic regression analysis showed that fecal occult blood positive,CA125,CAEA,CA199 and AFP levels were all risk factors for colon cancer.Binomial Logistic regression analysis showed that CA125 level and fecal occultation blood index increased as independent risk factors for colon cancer,and the differences were statistically significant(P<0.05).Conclusion:The positive rate of four serum tumor markers CA125,CEA,CA199 and AFP combined with fecal occult blood test is higher in the diagnosis of Dukes STAGE B colon cancer.