高血压个体化用药基因检测在Ⅲ级高血压患者中的应用

Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension

目的探讨应用高血压个体化用药基因检测能否改善高血压患者疗效。方法纳入Ⅲ级高血压住院患者200名,随机分为2组,一组为基因检测组,共100名患者,入院进行高血压个体化用药基因检测,然后根据基因检测结果进行针对个体化的精准降压治疗;另一组为常规治疗组,共100名患者,按照以往常规根据经验降压治疗。记录患者血压达标的时间、降压药物副作用以及住院日情况。结果(1)患者住院4 d内血压达标率基因检测组41%vs常规治疗组17%,药物副作用发生率基因检测组13%vs常规治疗组27%,基因检测组均显著优于常规治疗组,差异有统计学意义(P<0.05);(2)患者平均住院日基因检测组(5.42±3.24)d vs常规治疗组(6.26±3.43)d,基因检测组显著低于常规治疗组,差异有统计学意义(P<0.05)。结论(1)高血压个体化用药基因检测能改善高血压患者疗效;(2)高血压个体化用药基因检测可缩短高血压患者平均住院日。

Objective To explore the effectiveness of gene detection in improving individualized medication’s curative effect in patients with hypertension.Methods 200 inpatients with grade 3 hypertension were randomly divided into two groups.There were 100 patients in the gene testing group.After admission,personalized drug genetic testing was performed for hypertension,and then individualized precise antihypertensive therapy was performed according to the results of gene testing.The other group was the rontine treatment group,a total of 100 patients,according to previous conventional treatment based on experience.The time of blood pressure compliance,side effects of antihypertensive drugs and hospital stay were recorded.Results The blood pressure compliance rate of patients within 4 d in hospital was 41%in gene testing group versus 17%in rontine treatment group,and the incidence of drug side effects was 13%in gene testing group versus 27%in rontine treatment group.Gene testing group was significantly better than rontine treatment group,with statistical significance(P<0.05).Average length of hospital stay in gene testing group(5.42±3.24)d vs rontine treatment group(6.26±3.43)d,gene testing group was significantly lower than rontine treatment group,the difference was statistically significant(P<0.05).Conclusion Gene detection of individualized medication for hypertension can improve the curative effect of patients with hypertension and shorten the average hospital stay of patients with hypertension.