灯盏花乙素抗氧化应激机制在防治心脑血管疾病中的研究进展

Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases

灯盏花乙素,化学名为4,5,6-三羟基黄酮-7-葡糖苷酸,是中国传统中药灯盏花的主要活性成分。临床上,因其具有极其广泛的生物活性而被用于治疗心脑血管疾病。近年来,以高发病率、高死亡率为特点的心脑血管疾病已经成为中老年人的常见多发病,并随着人们饮食结构的转变,不良生活习惯的养成使该病的发病有了年轻化的趋势。氧化应激是心脑血管疾病发生、发展中极其重要的因素。而灯盏花乙素对心脑血管疾病的治疗有较好疗效,不难发现,灯盏花乙素对氧化应激有一定的抑制作用。旨在对灯盏花乙素与氧化应激的作用机制进行综述,并探讨灯盏花乙素对氧化应激抑制作用在临床上的应用,从而为今后临床疾病的治疗提供一定的参考。

Scutellarin,chemically named 4,5,6-trihydroxyflavone-7-glucosidic acid,is the main active ingredient of the traditional Chinese medicine Breviscapus.Clinically,it has been used in the treatment of cardiovascular and cerebrovascular diseases because of its extremely wide biological activities.In recent years,cardiovascular and cerebrovascular diseases characterized by high morbidity and mortality have become common and frequently-occurring diseases among middle-aged and elderly people.With the change of people’s diet,unhealthy life style,the onset of the disease has a trend of younger age.Studies have shown that oxidative stress is an extremely important factor in the occurrence and development of cardiovascular and cerebrovascular diseases.Scutellarin has a better therapeutic effect on the treatment of cardiovascular and cerebrovascular diseases.Therefore,it is not difficult to find that scutellarin has a certain inhibitory effect on oxidative stress.This article reviews the mechanism of scutellarin and oxidative stress,and to explore the clinical application of scutellarin to inhibit oxidative stress,so as to provide a certain evidence for the treatment of clinical diseases in the future.