广泛性焦虑障碍患者人格特征与免疫功能、甲状腺激素和神经内分泌激素的相关性分析

Correlation Analysis between Personality Characteristics and Immune Function, Thyroid Hormone and Neuroendocrine Hormone in Patients with Generalized Anxiety Disorder

目的:探讨广泛性焦虑障碍(GAD)患者人格特征与免疫功能、甲状腺激素和神经内分泌激素的相关性。方法:选择2019年1月~2020年12月北部战区空军医院心理科收治的GAD患者80例作为研究组,选择同期于北部战区空军医院体检的健康志愿者80例作为对照组。应用艾森克人格问卷简式量表中国版(EPQ-RSC)对受试者人格特征进行评价,比较两组EPQ-RSC评分结果、血液中CD3^(+)、CD4^(+)、自然杀伤细胞(NK)比例,血清白细胞介素(IL)-2、IL-6,三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、去甲肾上腺素(NE)、促肾上腺皮质激素(ACTH)、皮质醇(CS)水平,并分析其相关性。结果:研究组精神质(P)、神经质(N)评分及EPQ-RSC总分均显著高于对照组(P<0.05),研究组CD3^(+)、CD4^(+)、NK比例显著低于对照组,血清IL-2、IL-6水平显著高于对照组(P<0.05)。研究组血清FT3、FT4水平显著低于对照组(P<0.05)。研究组血清CS水平显著低于对照组,NE、ACTH水平显著高于对照组(P<0.05)。Pearson相关分析显示,GAD患者N、P评分及EPQ-RSC总分与CD3^(+)、CD4^(+)、NK、FT3、FT4、CS呈负相关(P<0.05),与IL-2、IL-6、NE、ACTH呈正相关(P<0.05)。结论:GAD患者存在免疫功能损伤、神经内分泌激素和甲状腺激素水平异常,且均与患者P、N倾向的人格特征有关。

Objective:To explore the correlation between personality characteristics and immune function,thyroid hormone and neuroendocrine hormone in patients with generalized anxiety disorder(GAD).Methods:80 patients with GAD who were treated in Department of Psychology,Northern Theater Air Force Hospital from January 2019 to December 2020 were selected as the study group,and80 healthy volunteers who underwent physical examination of the Northern Theater Air Force Hospital in the same period served as the control group.The simple Eysenck Personality Questionnaire(EPQ-RSC)was used to evaluate the personality characteristics of the subjects.The results of EPQ-RSC score,the proportions of CD3^(+),CD4^(+)and natural killer(NK)cells in blood,serum interleukin(IL)-2 and IL-6,triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),norepinephrine(NE),adrenocorticotropin(ACTH)and cortisol(CS)levels were compared between the two groups,and their correlation were analyzed.Results:The psychoticism(P),neuroticism(N)and EPQ-RSC total scores in the study group were significantly higher than those in the control group(P<0.05),CD3^(+),CD4^(+)and NK in the study group were significantly lower than those in the control group,and IL-2 and IL-6 were significantly higher than those in the control group(P<0.05).FT3 and FT4 in the study group were significantly lower than those in the control group(P<0.05).CS in the study group was significantly lower than that in the control group,NE and ACTH were significantly higher than those in the control group(P<0.05).Pearson correlation analysis showed that N,P and EPQ-RSC total scores were negatively correlated with CD3^(+),CD4^(+),NK,FT3,FT4 and CS of GAD(P<0.05),and positively correlated with IL-2,IL-6,NE and ACTH(P<0.05).Conclusion:Patients with GAD have impaired immune function and abnormal levels of neuroendocrine hormone and thyroid hormone,which are related to P and N propensity personality characteristics of patients.