盐酸倍他司汀片联合盐酸氟桂利嗪片对椎-基底动脉供血不足性眩晕症患者椎基底动脉血流动力学和生活质量的影响

Effects of Betahistine Hydrochlonde Tablet Combined With Flunarizine Hydrochloride Tablet on Vertebrobasilar Hemodynamics and Quality of Life in Patients with Vertebrobasilar Insufficiency Vertigo

目的:观察盐酸倍他司汀片联合盐酸氟桂利嗪片对椎-基底动脉供血不足(VBI)性眩晕症患者椎基底动脉血流动力学和生活质量的影响。方法:选择2019年5月~2021年2月期间来我院就诊的97例VBI性眩晕症患者,根据乱数表法,入选的患者分为对照组和观察组,分别为48例和49例,对照组接受盐酸倍他司汀片治疗,观察组接受盐酸倍他司汀片联合盐酸氟桂利嗪片治疗,均治疗2周。对比两组疗效、药物不良反应、眩晕症状评分、生活质量、椎基底动脉血流动力学情况。结果:观察组的临床总有效率(93.88%)高于对照组(72.92%)(P<0.05)。治疗2周后,观察组的眩晕评定量表的评分系统(DARS)、眩晕障碍量表(DHI)评分低于对照组(P<0.05)。治疗2周后,观察组的36项健康调查简表(SF-36)各维度评分均高于对照组(P<0.05)。治疗2周后,观察组的左侧/右侧椎动脉及基底动脉血流速度较对照组高(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。结论:盐酸倍他司汀片联合盐酸氟桂利嗪片治疗VBI性眩晕症患者疗效显著,可有效改善其椎基底动脉血流动力学状况,缓解眩晕症状,提高生活质量。

Objective: To observe the effects of betahistine hydrochlonde tablet combined with flunarizine hydrochloride tablet on vertebrobasilar hemodynamics and quality of life in patients with vertebrobasilar insufficiency(VBI) vertigo. Methods: 97 patients with VBI vertigo who came to our hospital from May 2019 to February 2021 were selected. According to the random number table method,the selected patients were divided into control group and observation group, 48 cases and 49 cases respectively. The control group was treated with betahistine hydrochlonde tablet, and the observation group was treated with betahistine hydrochlonde tablet combined with flunarizine hydrochloride tablet, all patients were treated for 2 weeks. The curative effect, adverse drug reactions, vertigo symptom score,quality of life and vertebrobasilar hemodynamics were compared between the two groups. Results: The total clinical effective rate of the observation group(93.88%) was higher than that of the control group(72.92%)(P<0.05). 2 weeks after treatment, the scores of vertigo Assessment Scale(DARS) and vertigo Disorder Questionnaire(DHI) of the observation group were lower than those of the control group(P<0.05). 2 weeks after treatment, the scores of each dimensions of 36-Item Health Survey(SF-36) of the observation group were higher than those of the control group(P<0.05). 2 weeks after treatment, the blood flow velocities of left/right vertebral artery and basilar artery of the observation group were higher than those of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Betahistine hydrochlonde tablet combined with flunarizine hydrochloride tablet in the treatment of patients with VBI vertigo has a significant effect, can effectively improve the vertebrobasilar artery blood flow dynamics, relieve vertigo symptoms, improve the quality of life.