miR-132和miR-1285在上皮性卵巢癌中的表达及意义

Expressions and significance of miR-132 and miR-1285 in epithelial ovarian cancer

目的探讨微小RNA-132(miR-132)和微RNA-1285(miR-1285)在上皮性卵巢癌组织中的表达及意义。方法选取2016年1月至2019年1月间西安市人民医院收治的39例卵巢癌患者,收集患者手术切除的上皮性卵巢癌组织及癌旁正常组织,比较两组组织中miR-132和miR-1285的表达情况及与患者病理参数的关系。结果卵巢癌组织中miR-132和miR-1285表达均低于癌旁正常组织,差异均有统计学意义(均P<0.05)。miR-132和miR-1285表达水平均与患者年龄、组织学分型和病理分级无相关性(P>0.05);TNM分期均与miR-132和miR-1285表达水平有关(P<0.05),其中Ⅲ期低于Ⅱ期和Ⅰ期,Ⅱ期低于Ⅰ期。生存患者miR-132和miR-1285表达水平均高于死亡患者,差异均有统计学意义(均P<0.05)。结论上皮性卵巢癌患者miR-132和miR-1285表达较低,TNM分期Ⅲ期和Ⅱ期低,预后生存患者miR-132和miR-1285表达水平更高。

Objective To study expressions and significance of microRNA-132(miR-132) and microRNA-1285(miR-1285) in epithelial ovarian cancer and their relationship with clinical stage and prognostic survival. Methods Thirty-nine patients with ovarian cancer admitted to Xi’an People’s Hospital were selected from January 2016 to January 2019 with their epithelial ovarian cancer tissues and normal paracancerous tissues collected during surgical resection. Expressions of miR-132 and miR-1285 were compared between these two types of tissues and the relationship between expression levels of miR-132 and miR-1285 and the pathological parameters of ovarian cancer was analyzed. Results Compared with normal paracancerous tissues, the expression of miR-132 and miR-1285 were significantly low in ovarian cancer tissues(all P<0.05). The expression level of miR-132 and miR-1285 were not associated with age, tissue type and pathology grading(P>0.05). TNM staging was associated with the expression level of miR-132 and miR-1285(all P<0.05). The expression level of miR-132 and miR-1285 was lower in patients with stage Ⅲ cancer than in patients with stage I and Ⅱ cancer. Compared with patients who’ve died, the expression levels of miR-132 and miR-1285 were significantly high in surviving patients(all P<0.05). Conclusion The expressions of miR-132 and miR-1285 are significantly reduced in patients with epithelial ovarian cancer and in patients TNM stage Ⅲ and Ⅱ cancer. The expression levels of miR-132 and miR-1285 are significantly high in surviving patients.