摘要
Mer(monocytesepithelial tissue reproductive tissue)激酶参与调节细胞分化、存活、迁移及炎症细胞因子的释放等复杂生理进程,其过度表达可导致肿瘤的发生、增殖和侵袭等,因此抑制Mer激酶活性已成为肿瘤治疗的新策略。本文对Mer激酶的结构、生物学功能以及相关的小分子抑制剂的研究进展进行综述,并结合作者自身研发经历进行展望。
Mer receptor tyrosine mediates the cell differentiation, cell survival, cell motility, releasing inflammatory factors and other complex pathophysiologic proceedings.Abnormal activation or overexpression of Mer RTK has been implicated in neoplastic progression of many cancers.There fore, Mer inhibitors have drawn increasing attention.The recent research advances on small molecule Mer kinase inhibitors are reviewed in this paper.
作者
黄道伟
李晓林
张庆伟
李建其
张越
HUANG Dao-wei;LI Xiao-lin;ZHANG Qing-wei;LI Jian-qi;ZHANG Yue(School of Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang,050018,China;Hebei Pharmaceutical and Chemical Engineering Technology Research Center,Shijiazhuang 05001S,China;Hebei Provincial Key Laboratory of Pharmaceutical Molecular Chemistry,Shijiazhuang 0500X8,China;Shanghai Institute of Pharmaceutical Industry Co.,Ltd.,China State Institute of Pharmaceutical Industry,Shanghai,201203,China;Shanghai Engineering Research Center of Pharmaceutical Process,Shanghai,201203,China)
出处
《中国药物化学杂志》
CAS
CSCD
2022年第2期142-151,共10页
Chinese Journal of Medicinal Chemistry
基金
国家自然科学基金青年基金项目(82003601)
河北省2020年度引进留学人员资助项目(C20200325)。
