金天格胶囊联合地奥司明治疗腰椎间盘突出症的临床研究

Clinical study on Jintiange Capsules combined with diosmin in treatment of lumbar disc herniation

目的探讨金天格胶囊联合地奥司明片治疗腰椎间盘突出症的临床疗效。方法选取2020年2月—2021年7月郑州市骨科医院收治的104例腰椎间盘突出症患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各52例。对照组口服地奥司明片,0.45g/次,2次/d。治疗组在对照组治疗的基础上温水送服金天格胶囊,1.2g/次,3次/d。两组患者共连续治疗3个月后统计疗效。观察两组的临床疗效,比较两组疼痛程度、腰椎功能和血清中前列腺素E_(2)(PGE_(2))、神经肽(NPY)、5-羟色胺(5-HT)水平。结果治疗后,治疗组总有效率为94.23%,明显高于对照组的80.77%,差异有统计学意义(P<0.05)。治疗1、3个月后,两组VAS评分均显著降低(P<0.05),且治疗组比对照组同期VAS评分减轻更明显,差异有统计学意义(P<0.05)。治疗后,两组的日本骨科协会腰椎功能量表(JOA)评分均显著提高(P<0.05);且治疗组的JOA评分改善程度比对照组高(P<0.05)。治疗后,两组的PGE_(2)、NPY、5-HT水平均显著下降(P<0.05);且治疗组的PGE_(2)、NPY、5-HT水平低于对照组,差异有统计学意义(P<0.05)。结论金天格胶囊联合地奥司明片治疗腰椎间盘突出症具有较好的临床疗效,可改善腰椎功能,降低患者疼痛程度,调节PGE_(2)、NPY、5-HT水平,安全性较好。

Objective To investigate the effect of Jintiange Capsules combined with Diosmin Tablets in treatment of lumbar disc herniation.Methods Patients(104 cases)with cerebral infarction in Zhengzhou Orthopedic Hospital from February 2020 to July 2021 were randomly divided into control and treatment groups,and each group had 52 cases.Patients in the control group were po administered with Diosmin Tablets,0.45 mg/time,twice daily.Patients in the treatment group were po administered with Jintiange Capsules on the basis of the control group,1.2 g/time,three times daily.Patients in two groups were treated for 3 months.After treatment,the clinical efficacies were evaluated,and pain degree,lumbar function,and the levels of PGE_(2),NPY,and 5-HT in two groups were compared.Results After treatment,the total effective rate of the treatment group was 94.23%,which was significantly higher than that of the control group(80.77%),with significant difference(P<0.05).After 1 and 3 months of treatment,the VAS scores of two groups were significantly decreased(P<0.05),and the VAS score of the treatment group was significantly lower than that of the control group at the same time(P<0.05).After treatment,the JOA scores of two groups were significantly increased(P<0.05),and the improvement of JOA score in the treatment group was higher than that in the control group(P<0.05).After treatment,the levels of PGE_(2),NPY,and 5-HT in two groups were significantly decreased(P<0.05),and the levels of PGE_(2),NPY,and 5-HT in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Jintiange Capsules combined with Diosmin Tablets has clinical curative effect in treatment of lumbar disc herniation,can improve lumbar function,reduce the degree of pain,and adjust the levels of PGE_(2),NPY,and 5-HT,with good safety.