桦褐孔菌活性组分提取分析方法研究进展

Research progress on extraction methods of Inonotus obliquus constituents

桦褐孔菌Inonotus obliquus属于多孔菌科褐卧孔菌属,是珍贵的药用真菌,分布于中国、芬兰、波兰、俄罗斯及日本等国家。桦褐孔菌具有抗衰老和抑制病毒的药理作用,主要用于治疗各种癌症、糖尿病及心脏病,主要成分为多糖、三萜类化合物、木质素及黑色素,其提取分离方法主要涉及水提法、超声法、微波辅助提取法、酶诱导结合负压空气化提取法,分析方法主要为薄层色谱法、高效液相法和紫外-分光光度法。天然产物在新药研发及新药先导化合物发现中起重要作用,综述了桦褐孔菌活性成分的提取及分析方法研究进展,以期为其深入研究及新药研发提供参考。

Inonotus obliquus is a valuable medicinal fungus belonging to the genus Obliquus of the family poraceae.It is distributed in China,Finland,Poland,Russia and Japan.It is mainly used worldwide to treat various cancers,diabetes and heart disease.In addition,it has anti-aging and anti-virus effects.The main ingredient of fo to the polysaccharides of fo,triterpene compounds,melanin and lignin,the extraction and separation methods mainly involves water,ultrasonic method,microwave assisted extraction,enzyme induction combined with negative pressure air extraction,analysis method for thin layer chromatography(TLC),high performance liquid(HPLC)and ultraviolet spectrophotometer method.Natural products play an important role in the discovery of new drugs and new drug lead compounds.In this paper,the extraction methods and analysis methods of active substances in Inonotus obliquus were reviewed,in order to provide reference for the further study of active substances in Inonotus obliquus e and the development of natural fungi as precursor compounds for new drug research and development.